Scientist, ADC In Vivo Pharmacology
About the role
Pfizer is seeking a highly motivated Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs, but including other large molecule and small molecule programs. This role supports the execution of high-quality in vivo efficacy, pharmacodynamic, tolerability, and mechanistic studies that enable preclinical discovery and development. The ideal candidate will demonstrate strong technical capability in oncology animal models, careful attention to study details, and a commitment to animal welfare, compliance, and scientific rigor. The Scientist is expected to contribute as a reliable technical and scientific team member while developing increasing independence in study execution, data interpretation, and cross-functional collaboration.
Responsibilities
- Execute in vivo oncology studies supporting discovery programs using a variety of in vivo models including human cell line‑derived, patient‑derived xenograft, syngeneic models as appropriate.
- Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration (IV, PO, subQ, IP dosing), clinical observations, and sample collection.
- Perform routine in vitro tissue culture procedures.
- Support pharmacology studies assessing efficacy, tolerability, pharmacodynamic biomarkers, dose‑response relationships, schedule optimization, and combination strategies.
- Prepare, review, and follow study protocols, dosing schedules, randomization plans, and sample collection timelines in alignment with project goals and internal standards.
- Maintain accurate, timely, and compliant study records using electronic data capture systems and approved documentation practices.
- Coordinate with project line leads, vivarium operations, pathology, toxicology translational scientists, bioanalytical, pharmacodynamic and pharmacokinetic teams, and external partners to enable efficient study execution.
- Assist with data quality review, graphical summaries, and interpretation of in vivo study results.