Scientist 3 - Translational Medicine (Ophthalmology)

About the role

We are seeking a talented and highly motivated Scientist 3 to join Genentech’s Translational Medicine (TM) team on-site at our South San Francisco campus. This position uniquely bridges data science and the wet lab, requiring a blend of computational skills to interpret high-dimensional datasets and bench-level expertise to design and execute validation experiments.

Responsibilities

• Analyze high-dimensional datasets (e.g., proteomics, transcriptomics) generated from clinical and preclinical samples to discover novel therapeutic targets and candidate biomarkers.
• Design and execute experiments using disease-relevant in vitro human cell models to translate data-driven insights into functional biology.
• Lead and coordinate exploratory clinical studies in partnership with internal and external collaborators to advance translational research and discover clinical biomarkers.
• Collaborate closely with cross-functional R&D partners, including Research Biology, Computational Sciences, Tissue Genomics & Proteomics, Biostatistics, Clinical Pharmacology, and Bioanalytical Sciences.
• Develop and qualify custom assays (e.g., Simoa, NULISA) for biomarkers of interest, moving beyond standard commercial kits to build bespoke solutions for pipeline programs.
• Communicate insights effectively across the organization and the broader scientific community through high-quality reports, presentations, and peer-reviewed publications.

Requirements

• A PhD in Biological Sciences (including neuroscience, immunology, cell biology, or a related field) with 0–4 years of relevant post-graduate experience.
• Exceptional candidates without a PhD but with an equivalent track record of rigorous scientific experience are also encouraged to apply.
• While clinical or translational experience in retinal biology is preferred, it is not required.
• Broad biological expertise with a clear passion for translating science into life-changing therapies.
• Proven track record of executing both wet-lab experiments and bioinformatic analyses to answer complex biological questions, as demonstrated through a strong peer-reviewed publication record.
• Deep technical wet-lab expertise in preclinical/clinical sample analysis and molecular biology techniques (including cell culture, ELISA, qPCR, and NGS/transcriptomics).
• Computational proficiency with hands-on experience programming in R or Python to apply biostatistical and bioinformatics methods to high-dimensional datasets.
• Demonstrated scientific independence, outstanding organizational and teamwork skills, scientific curiosity, and exceptional communication abilities.

Qualifications

• PhD in Biological Sciences (including neuroscience, immunology, cell biology, or a related field)
• 0–4 years of relevant post-graduate experience
• Experience in high-dimensional dataset analysis and experimental design
• Programming experience in R or Python
• Experience with wet-lab techniques and bioinformatics
• Excellent communication and collaboration skills

Skills

• Data analysis and interpretation
• Experimental design and execution
• Collaboration and teamwork
• Communication and presentation skills
• Custom assay development and qualification

Benefits

The expected salary range for this position based on the primary location of California is $100,400 -186,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.