Scientist 3, Cell Therapy - T Cell Biology

About the Role

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated scientist to help develop novel cell therapies for patients with intractable diseases. The successful candidate will bring scientific rigor, creativity, and a resourceful approach to solving complex biological and technical problems. This individual will work across diverse scientific and functional teams to advance Genentech’s cell therapy pipeline and contribute to the scientific direction, collaborative culture, and continued growth of the Cell Therapy department.

Responsibilities

• Culture and engineer primary T cells and other relevant cell types.
• Develop and apply multiparameter flow cytometry assays to characterize T cell identity, differentiation state, activation, function, and fitness.
• Evaluate engineered T cells using appropriate phenotypic and functional assays, including proliferation, cytokine production, cytotoxicity, and persistence-related measurements.
• Analyze complex datasets, draw incisive conclusions, and use results to guide subsequent experimental strategy.
• Collaborate effectively with research, translational, computational, process development, and other partner groups across and outside gRED.
• Maintain comprehensive and accurate experimental records using electronic laboratory systems.
• Communicate findings clearly through written reports, data packages, and presentations to project teams and other stakeholders.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader cell therapy pipeline.

Requirements

• PhD, MD, DVM, or equivalent degree with at least 3 years of relevant experience.
• Extensive hands-on experience with primary T cell isolation, activation, culture, expansion, and phenotypic characterization.
• Deep knowledge of T cell biology, including development, differentiation, effector function, exhaustion, memory, and survival.
• Advanced experience in multiparameter flow cytometry, including panel design, selection of appropriate controls, assay optimization, data analysis, and biological interpretation.
• Experience engineering primary immune cells using viral and non-viral gene delivery methods.
• Experience developing and executing cell-based functional assays relevant to T cell biology or cell therapy.
• Demonstrated ability to design rigorous experiments, troubleshoot complex technical problems, and interpret multidimensional datasets.
• A record of scientific, technical, or process improvement contributions in a relevant field, demonstrated through publications, patents, regulatory submissions, or meaningful contributions to therapeutic programs.
• Strong organizational and communication skills, including the ability to document, present, and discuss results with multidisciplinary audiences.
• A collaborative mindset and demonstrated ability to advance shared objectives across project teams.
• A strong work ethic grounded in scientific curiosity, rigor, attention to detail, and a commitment to high-quality research.

Preferred Qualifications

• Knowledge of human T cell development, lineage specification, or thymic biology.
• Familiarity with high-dimensional or spectral flow cytometry and associated analysis tools.
• Experience developing CAR-T, TCR-T, or other engineered T cell therapies.
• Knowledge of CAR design, vector biology, T cell manufacturing, or critical quality attributes relevant to engineered T-cell products.
• Experience with CRISPR-based or other genome-engineering technologies in primary T cells.
• Experience culturing and engineering human induced pluripotent stem cells (iPSCs).
• Experience differentiating iPSCs or hematopoietic progenitors toward immune or T-cell lineages.
• Experience working within multidisciplinary cell therapy discovery or development teams.
• Familiarity with in vivo models of liquid and solid tumors.

Pay

The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

Benefits

This position qualifies for the benefits detailed at the provided link. Relocation benefits are available for this posting.