Scientist Cell Therapy (R&D)

About the role

This is a hands-on, laboratory-focused position.

Responsibilities

• Develop routine drug discovery research experiments and analytical studies to identify and validate potential novel drug targets, applying diverse methodologies, with minimal supervision.
• Conduct experiments and interpret results by using established scientific methodologies and tools.
• Modify or improve existing research processes and systems to better align with experimental objectives.
• Assess and report experimental data with minimal guidance, ensuring clarity, relevance, and connection to the broader drug discovery context.
• Present and defend experimental findings during follow-up meetings or in relevant forums.
• Manage personal workload efficiently to achieve agreed-upon targets within specific time limits and quality standards, while also providing routine updates on progress.
• Provide technical mentorship to team members on experimental procedures and allocate administrative tasks when necessary.
• Collaborate with project teams to facilitate seamless communication and data sharing within the team.
• Search for information which may improve research methodology and procedures.
• Ensure work is performed in compliance with Safety, Health & Environment (SHE), quality, and regulatory requirements, including laboratory standards (GLS).

Requirements

• Bachelor’s degree (or equivalent 3-4 years of experience) in a relevant field with demonstrated experience in Cellular Therapy, Immunology, and/or Immuno-Oncology.
• 2+ years of industry experience.
• Extensive in vivo skills including animal handling, syngeneic murine, xenograft and PDX tumour models, standard routes of dosing and engraftment, tissue processing, PK/PD and efficacy studies.
• Proficiency in tail vein dosing.
• Well-developed understanding of molecular and cellular biology, immunological assays.
• Effective interpersonal skills.
• Ability to develop, implement, and troubleshoot experiments independently.

Qualifications

• Experience with a range of in vitro assays, including but not limited to ELISA, multicolor flow cytometry.
• In vitro and in vivo experience with murine T cells.
• Basic experience developing cellular therapies including CAR-T/ CAR-NK, TCR-T, and/or TIL therapies.
• Background in drug discovery and development in the pharmaceutical industry.
• Experience with complex in vivo systems, including but not limited to orthotopic xenograft models, humanized mice, in vivo imaging of luciferase labelled tumor models.

Key Relationships

• Internal: Colleagues, senior staff and management; AZ project teams.
• External: External scientific community.