Research Scientist I / II – High Throughput Chemistry

About the role

We are seeking a highly skilled and motivated Research Scientist to join our Discovery Chemistry team at Iambic Therapeutics in San Diego, CA. In this role, the ideal candidate will exploit their strong background in organic synthesis, catalysis, and reaction development to design, optimize, and execute high-throughput experiments to drive compound library campaigns. The successful candidate will deliver impact cross-functionally with chemistry, biology, compound management, AI/ML, and software teams across the discovery pipeline, leveraging Iambic's HTE platform to accelerate and strengthen our programs. This position will be based in our San Diego Headquarters.

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Responsibilities

• Design and execute parallel synthetic methods to generate large, high-quality compound libraries.
• Identify, develop, and optimize novel synthetic methodologies with a focus on automation compatibility and HTE scalability.
• Apply newly developed synthetic routes from traditional bench-scale chemistry to robust, high-throughput, and automated processes.
• Oversee the operation, maintenance, and continuous advancement of our chemistry toolkit and automated synthesis equipment.
• Analyze research outcomes and library compound data and clearly communicate results and findings to cross-functional project teams.
• Ensure all laboratory work is conducted in accordance with established safety protocols and best laboratory and ELN data recording practices.
• Function as a core