Senior Scientist, High-Throughput Chemistry
About Us
Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Jnana’s lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, and a highly experienced management team. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn. At Jnana, you'll join a diverse, passionate team dedicated to advancing therapies for challenging diseases. Our collaborative, purpose-driven culture fosters innovation, urgency, and belonging—making Jnana a great place to work!
About the Opportunity
As a Scientist in our Discovery Chemistry group, you will support our internal chemistry group focused on drug discovery programs for hard-to-drug targets. Through small molecule screening using our novel and proprietary chemoproteomics RAPID platform, our research aims to identify novel small molecules against these challenging targets to interrogate target biology and ultimately to develop drug candidates that can provide clinical value to patients.
Come discover more about Otsuka and our benefit offerings; https://www.otsuka-us.com/careers-join-otsuka.
Responsibilities
- Execute direct-to-biology, high-throughput chemistry to support the platform
- Develop and optimize new reactions for direct-to-biology chemistry
- Contribute to establishment of the high-throughput chemistry function and planning/build out of laboratory automation
- Utilize synthetic expertise to design and execute synthesis of target molecules
- Work closely with external chemistry CRO teams to synthesize target molecules
- Work collaboratively across scientific disciplines on multiple projects
- Proactively engage in brainstorming and the generation of new ideas across projects
- Assist in preparing patent applications and publications
- Maintain a safe and productive laboratory environment