Senior Scientist, Computational Chemistry

About the role

Research and Development is at the heart of Pfizer's mission to deliver breakthroughs that change patients' lives. This role is within Medicinal Chemistry and involves supporting molecular design, data interpretation, and hypothesis generation.

Responsibilities

• Apply established computational chemistry methods to support molecular design, data interpretation, and hypothesis generation under the guidance of experienced scientists.
• Use computational approaches to help prioritize molecules, interpret structure-activity relationships, and support design ideas.
• Contribute to project discussions, communicate results clearly, and work with senior computational chemists and experimental colleagues to refine analyses and identify the next practical steps for drug discovery projects.

Qualifications

• Ph.D. in computational chemistry, chemistry, biophysics, computational biology, or a related discipline; or M.S. with relevant research experience.
• 0-2 years of postdoctoral, academic, or industry experience in computational chemistry or a related field.
• Experience contributing to research projects through graduate work, postdoctoral training, internships, co-ops, or collaborative project experience is acceptable.
• Working knowledge of one or more computational chemistry areas, such as molecular docking, structure-based design, ligand-based design, molecular visualization, conformational analysis, or cheminformatics.
• Strong understanding of physical chemistry, protein-ligand interactions, and structure-activity relationships.
• Familiarity with common molecular modeling software and willingness to learn additional tools and workflows.
• Proficient scripting or data analysis skills, preferably in Python; experience with Linux or high-performance computing environments is a plus but not required.
• Ability to analyze results carefully, document work clearly, and communicate scientific findings to project team members.
• Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity.
• Demonstrated curiosity for exploring how these tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use.

Additional Information

Relocation support available
Work Location: On Premise
Last Day to Apply: July 24, 2026
Annual base salary range: $93,600.00 - $156,000.00
Eligible for Global Performance Plan with a bonus target of 12.5% of the base salary and participation in share-based long-term incentive program.
Benefits include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.