Research Fellow - Translational Omics Program

About the role

The Research Fellow will join the Translational Omics Program (TOP) and the Department of Medicine (DOM) led Omics-based Research for Identifying Genomic Insights and New Therapies (ORIGIN) initiative at Mayo Clinic. ORIGIN is a bench-to-bedside translational research program designed to bridge multi-omics discovery with real-time clinical application across DOM divisions.

Responsibilities

• Design and lead translational research projects aligned with ORIGIN priorities, including patient identification, precision diagnosis, targeted therapy, and discovery
• Apply and integrate multi-omics data (genomics, transcriptomics, proteomics, metabolomics) to investigate disease mechanisms and therapeutic opportunities
• Collaborate with clinical teams, genetic counselors, laboratory scientists, and external partners to translate findings into clinical or experimental follow-up
• Fundamentally understand the current best-practice principles guiding genetic variant interpretation in the context of rare and undiagnosed diseases, as well as preventive (i.e. 'healthy screen') testing
• Contribute to the development and improvement of analytical workflows for -omic data types and data integration
• Present genetic findings and variant interpretation regularly to internal and external groups
• Contribute to genotype-first and cohort-based studies leveraging population-scale resources (e.g., biobanks, reverse phenotyping)
• Incorporate computational, statistical, or AI-assisted approaches as appropriate to support biological and clinical questions
• Communicate results through presentations, manuscripts, and participation in multidisciplinary case and research conferences
• Establish and maintain internal and external scientific collaborations
• Routinely write and publish scientific research, case reports, and methods papers

Qualifications

• MD, PhD, or MD/PhD in genetics, genomics, molecular biology, computational biology, or a related biomedical field
• Demonstrated research experience in translational science, functional genomics, or multi-omics analysis
• Strong interest in clinically relevant research and team-based translational science
• Evidence of scholarly productivity (peer-reviewed publications)
• Ability to work collaboratively in a multidisciplinary research environment