Research Associate - Systems Biology & Phage Therapy (Silas Lab)

About the role

The RA will collaborate closely with the PI (Sukrit Silas) and contribute to high-impact research, with the potential to publish one or more papers within a two-year period. This role is particularly well-suited for individuals considering graduate, medical, or dental school.

Responsibilities

• Collaborate with the PI (Sukrit Silas) to develop and optimize high-throughput phage-host screening protocols using a broad range of molecular biology techniques, such as: High-efficiency electroporation and transformation of bacteria for library construction Restriction enzyme cloning, Gibson Assembly, Golden Gate Assembly PCR and gel electrophoresis of various molecules such as nucleic acids, glycoproteins, and lipopolysaccharides DNA/RNA purification and NGS sample preparation Whole genome transposon mutagenesis
• Maintain rigorous sample tracking and organization across numerous parallel workflows
• Lead and meticulously document complex projects using Benchling
• Assist with research planning, including primer and vector design, experimental execution, analysis, troubleshooting, and data interpretation
• Maintain detailed experimental records and present findings at regular team meetings
• Manage general laboratory operations, including reagent procurement, inventory organization, and compliance with safety regulations

Requirements

• Bachelor’s degree (BA/BS) in Cell and Molecular Biology or a related field, with at least one year of hands-on research laboratory experience (preferred)
• Strong ability to work independently, demonstrating initiative and problem-solving skills
• Exceptional attention to detail, with excellent organizational, verbal, and written communication skills
• Proactive approach to learning new techniques and optimizing protocols
• Effective time management skills, with the ability to prioritize tasks, collaborate with team members, and meet multiple deadlines
• Commitment to following established policies and procedures
• Availability for evening and weekend hours as required; this is a full-time, in-person position based in Mission Bay, San Francisco

Qualifications

• Experience in bacterial cell culture maintenance and transformation
• Experience in high-throughput or high-volume sample workflows
• Proficiency in molecular biology techniques, including: PCR, DNA extraction and purification, gel electrophoresis DNA construct design and cloning DNA library construction and sequencing (Sanger and NGS) Protein expression and analysis techniques (e.g., Western blotting)
• Previous experience with laboratory management and inventory organization

Skills

• Nice to have: Experience with RNA and bacteriophage handling Proficiency in Microsoft Office Suite (Word, Excel)

Benefits

Gladstone Perks & Benefits: people–work with talented, committed, and supportive teammates within an organization that values each member of its community. A meaningful place to grow and learn–whether it’s your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone’s mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and excellent environment. Healthy work/life balance–you are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work. Compensation–competitive salary. Title and salary will be commensurate with education and experience. Excellent benefits–generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.