Research Associate in Department of Physiology

Location: Philadelphia, PA | Open Date: Jun 02, 2026 | Deadline: Jun 02, 2028 at 11:59 PM Eastern Time

About the role

The Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal are based on satisfactory performance and availability of funding (limited to three (3) years).

Responsibilities

• Conducting independent and collaborative research in structural proteomics, chemical biology, and mitochondrial biology
• Developing and implementing mass spectrometry-based workflows including chemical crosslinking mass spectrometry (XL-MS), quantitative proteomics, and protein interaction mapping
• Operating and maintaining advanced LC-MS/MS instrumentation
• Analyzing complex proteomics datasets
• Mentoring students and trainees
• Contributing to manuscript preparation, grant writing, and collaborative research projects
• Establishing and leading new structural proteomics and crosslinking mass spectrometry capabilities within a newly established research program
• Developing independent research projects at the interface of proteomics, structural biology, neuroscience, and reproductive biology
• Collaborating with investigators across Penn's structural biology, proteomics, mitochondrial biology, and neuroscience communities
• Receiving mentorship in laboratory leadership, grant writing, project development, and career advancement
• Contributing to high-impact interdisciplinary research programs

Qualifications

Ph.D. or M.D./Ph.D. degree

Skills and Expertise

• Expertise in mass spectrometry-based proteomics, including experience with LC-MS/MS instrumentation, experimental design, and proteomics data analysis
• Strong expertise in protein biochemistry, molecular biology, and quantitative proteomics approaches
• Strong record of original peer-reviewed publications, scientific leadership, communication, and interpersonal skills
• Experience with Orbitrap-based mass spectrometry platforms, quantitative proteomics workflows, and advanced proteomics software tools

Preferred Qualifications

• Expertise in chemical crosslinking mass spectrometry (XL-MS), structural proteomics, protein interaction mapping, chemical biology, development of novel analytical methodologies, and computational analysis of proteomics datasets
• Experience with mitochondrial biology, neuroscience, reproductive biology, cryo-EM, or integrative structural biology (desirable but not required)