Research Associate II/ Senior Research Associate, Therapeutics

About the Role

Join our Therapeutics team as a hands-on scientist and help translate CRISPR-based epigenetic therapies into clinical candidates. You'll design and execute experiments, drive data-driven problem-solving, and take increasing ownership of projects targeting ocular and rare genetic diseases. This is an excellent opportunity to grow in a dynamic biotech environment, working at the bench to unlock the therapeutic potential of CRISPR-based gene regulation.

Responsibilities

• Design, execute, analyze, and interpret in vitro experiments that support therapeutic candidate discovery and advancement.
• Develop and optimize assays to evaluate CRISPR-based epigenetic editing systems.
• Generate high-quality datasets and apply rigorous analysis to support data-driven program decisions.
• Partner closely with cross-functional teams to advance therapeutic programs.
• Prepare tissue blocks in OCT, perform cryosectioning, immunofluorescence, and fluorescent imaging.
• Culture, engineer, and characterize mammalian cell lines, primary cells, and iPSC-derived disease models.
• Perform molecular and cellular analyses including qPCR, RT-qPCR, digital PCR, western blotting, ELISA, flow cytometry, and next-generation sequencing-based assays.
• Evaluate AAV delivery and activity of gene therapy modalities.
• Maintain detailed and up-to-date experimental records and contribute to study reports and presentations.
• Stay current with emerging technologies and scientific advances in CRISPR, epigenetics, gene therapy, and ocular disease research.

Requirements

Research Associate II

• B.S. or M.S. in Molecular Biology, Cell Biology, Genetics, Neuroscience, Biomedical Engineering, or related field.
• 3–5+ years of relevant industry experience.

Senior Research Associate

• B.S. or M.S. with 5–8+ years of industry experience.
• Demonstrated ability to independently execute complex studies and contribute to experimental strategy.

Skills

• Strong molecular biology skills including nucleic acid extraction, PCR, qPCR, dPCR, cloning, and gene expression analysis.
• Mammalian cell culture and cellular assay development experience.
• Experience working with human or mouse tissues, preparing frozen tissue blocks, and cryosectioning.
• Experience with viral vector systems (AAV/lentivirus).
• Proficiency in flow cytometry, immunofluorescence staining, microscopy, and protein expression analyses.
• Strong data analysis, experimental design, and troubleshooting skills.

Preferred Qualifications

• Experience in epigenetics, chromatin biology, transcriptional regulation, or gene expression control.
• Experience working with ocular diseases.
• Prior experience supporting preclinical therapeutic development programs in biotechnology or pharmaceutical settings.

Pay

The salary range for this position is $95,000 to $115,000 USD annually. The actual salary may vary based on factors such as individual education, experience, tenure, skills, abilities, internal equity, and geographic location.