Research Associate II/Senior Research Associate
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ, specializing in developing innovative cancer treatments using its established drug development platforms. The company focuses on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs), with multiple assets in various stages of clinical trials for solid tumor and hematologic indications. SystImmune also maintains a robust preclinical pipeline of potential cancer therapeutics in discovery and IND-enabling stages.
About the role
The Research Associate II/Senior Research Associate will assist in downstream protein purification, protein characterization, and process development. This position reports directly to a Downstream lead and supports downstream process development and tech transfer to a GMP manufacturing facility. The role involves operating both routine and advanced analytical instruments as well as protein purification systems. This is a full-time, onsite position at our new Bothell, WA location and may occasionally require work outside normal hours.
Responsibilities
- Assist in downstream process development of molecules in pre-clinical and clinical pipelines.
- Perform process development activities including buffer preparation, chromatography method development and execution, TFF, and filtration operations and development.
- Assist in performing routine purifications and analytical assays to support cell-line development, upstream, analytical, and formulation groups.
- Execute development experiments to produce scalable and robust purification processes via affinity chromatography, IEX, HIC, and CHT using the ÄKTA FPLC platform.
- Execute development experiments for viral inactivation, viral filtration, and tangential flow filtration processes.
- Generate low endotoxin production runs for pre-clinical studies.
- Perform routine HPLC/UPLC, CE, cIEF, Octet, ELISA, and other biophysical techniques to support upstream, downstream, and formulation process development.
- Compile, analyze, and report data for process development, tech transfer documentation, and other internal partners.
- Author standard operating procedures for biophysical assays and standard workflows.
- Participate in timeline planning.
- Other duties as assigned.
Requirements
- MS or BS in Protein Science, Chemical Engineering, Biochemistry, or a related field with relevant pharmaceutical or biotech experience.
- Research Associate II: 2+ years of industry experience.
- Senior Research Associate: BS with 5+ years of experience or MS with 3+ years of industry experience.
- Experience with protein chromatography and filtration methods, and protein analysis techniques.
- Ability to execute SOPs and biophysical assays, and experiments designed for process development of pipeline molecules independently.
Skills
- Hands-on experience with ÄKTA Protein Purification Systems and Unicorn software.
- SEC-HPLC/UPLC.
- Purification Process Development.
- Crossflow and Tangential Flow Filtration techniques.
- Column packing/unpacking.
- Viral inactivation and viral filtration process development / Viral clearance study.
- Low endotoxin production run.
- Process scale-down/scale-up.
Pay
The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a candidate’s qualifications, experience, and skills.
Benefits
- 100% paid employee premiums for medical, dental, and vision insurance.
- Short-term and long-term disability coverage.
- 401(k) plan with a 50% company match of up to 3% and a vesting schedule of 5 years.
- 15 PTO days per year, sick leave, plus 11 paid holidays.