Research Associate II/Senior Research Associate I – In Vivo

About the role

Monte Rosa Therapeutics is seeking a Senior Research Associate I/II to support the design and execution of in vivo proof‑of‑concept studies across oncology, inflammatory disease, and autoimmune disease programs. The position level (Senior Research Associate I/II) will be determined based on the candidate’s qualifications and experience.

Responsibilities

• Work closely with cross‑functional teams to execute in vivo pharmacology studies that characterize the activity and mechanism of action of novel compounds.
• Independently perform in vivo technical procedures in mice, including administration of test agents by oral, intraperitoneal, and subcutaneous routes; blood collection using multiple sampling methods or anatomical sites; tissue collection and necropsy procedures based on study requirements; preparation of compound formulations for dosing; and calculation of dose volumes and compound and formulation requirements.
• Design and conduct in vivo studies to characterize target biology and assess compound activity in disease‑relevant mouse models.
• Maintain accurate and complete laboratory records, study documentation, procedures, and data summaries.
• Perform evening and weekend animal dosing and other study‑related procedures as needed.
• Perform and document animal health assessments in accordance with approved IACUC protocols, institutional procedures, and animal‑welfare standards, and promptly report any identified concerns.
• Process time‑sensitive biological samples according to study requirements.
• Assist with oversight of breeding programs, including monitoring litters and documenting outcomes.
• Provide occasional support for cage changes and husbandry activities as needed.
• Perform cell culture work to support tumor studies for oncology programs.

Requirements

• BS/MS in Biology, Pharmacology, Animal Science, or a related field with a minimum of four years of relevant industry experience.

Skills

• Strong hands‑on experience working with laboratory animals, including test‑agent administration by oral, intraperitoneal, and subcutaneous routes; blood and tissue collection; and necropsy techniques.
• Prior experience safely preparing compound formulations and performing dose calculations.