Research Assistant / Laboratory Technician

Cambridge, MA · In-Person · Contractor-to-Full-Time

About Us

GT Biosciences is building Deliveromics, the world’s first AI-powered, high-throughput, and multiplexed in vivo data engine for decoding the design rules of drug delivery. Founded by MIT scientists and backed by top-tier investors, we are creating next-generation non-viral, cell-type-specific delivery vehicles for mRNA and siRNA. We are a tightly-knit, fast-moving, and science-driven team dedicated to making routine in vivo cell reprogramming a reality. We value transparency, collaboration, reliability, and scientific rigor, and seek teammates who thrive in an open, cooperative environment and want to grow together with the team and the company.

Responsibilities

• Prepare and formulate lipid nanoparticles and related non-viral delivery systems for mRNA and siRNA using established and evolving protocols.
• Support formulation screens by varying lipid composition, component ratios, buffers, mixing conditions, and other process parameters.
• Perform formulation characterization and quality control measurements (e.g., particle size, PDI, encapsulation efficiency, RNA concentration, pH, and fluorescence-based assays).
• Prepare high-quality formulations and samples for in vitro and in vivo studies, including dose calculations, labeling, quality control, and sample tracking.
• Maintain basic cell culture responsibilities and support transfection, expression, and knockdown assays as required.
• Handle precision liquid-handling tasks with accuracy and care (e.g., multichannel pipetting, reagent pooling, serial dilutions).
• Keep meticulous laboratory records and documentation, troubleshoot experiments thoughtfully, and repeat work carefully when results do not meet expectations.

Qualifications

Required

• B.S. or M.S. in Chemistry, Biochemistry, Bioengineering, Biology, Pharmaceutical Sciences, or a related field.
• At least 1+ years of meaningful hands-on experience in a wet laboratory setting (academic or industry).
• Demonstrated reliability, attention to detail, and strong commitment to accurate, thorough record-keeping.
• Proficiency with basic laboratory techniques (e.g., buffer preparation, serial dilution, accurate pipetting, and nucleic acid handling).
• A fast learner who is excited to develop unfamiliar wet-lab skills and become progressively more independent.
• Persistence when experiments fail, with the ability to stay calm, investigate possible causes, and improve the next attempt.
• A proactive, team-first attitude with strong ownership, clear communication, and consistent follow-through.
• Ability to work onsite five days per week at our Cambridge, MA location.

Preferred

• Exposure to lipid nanoparticles, liposomes, nanoparticle formulation, drug delivery, or microfluidic mixing.
• Experience handling RNA, including mRNA, siRNA, or other oligonucleotides.
• Experience with DLS, plate readers, UV spectroscopy, HPLC/UPLC, LC-MS, pH, osmolality, or endotoxin testing.
• Experience with mammalian cell culture, sterile technique, transfection, or cell-based assays.
• Experience with fluorescence microscopy or plate reader operation.
• Exposure to nucleic acid-based assays (e.g., hybridization, ligation, or amplification workflows).
• Basic cell culture skills (e.g., mammalian cell passaging, sterile technique).
• Proficiency with basic molecular biology techniques (e.g., running gels, making buffers, using DNA/RNA extraction kits).

Nice to Have

• Basic coding or data analysis skills (e.g., Python, R, or Excel for data organization).
• Familiarity with automated liquid handling or high-throughput screening platforms.
• Experience preparing formulations or samples for animal studies.
• Mouse intravenous injection, perfusion, or tissue collection experience.
• Strong interest in RNA medicines, drug delivery, and central nervous system therapeutics.

Pay

$22-$40 per hour (depending on experience)

Benefits

• Flexible, generous health benefits upon conversion to full-time employment.
• Work with a small, world-leading team that values rigorous science and candid collaboration.
• Learn directly from experts.
• Rapid professional growth through hands-on training and meaningful scientific ownership.