Research Assistant | Laboratory of Genome Maintenance

Organization Overview

Throughout its lifetime, a cell's DNA is under constant metabolic and environmental assault that can lead to damage. If left unchecked, the resulting genome instability can initiate cancer and a variety of other human disorders. Using Fanconi anemia and other genetic diseases as a backdrop, research in the Laboratory of Genome Maintenance, led by Dr. Agata Smogorzewska, aims to elucidate the pathways that protect organ function and prevent cancer, with a focus on those that replicate and repair DNA.

Overview

The Laboratory of Genome Maintenance seeks a research assistant to support basic and translational work on how DNA repair prevents cancer. A central responsibility will be processing samples from a chemoprevention trial expected to run for three years.

Responsibilities

• Process patient samples and perform a range of assays, including genomic DNA and RNA extraction, PCR, and sequencing library preparation in support of a clinical trial.
• Generate cell lines with specific DNA mutations, perform survival assays, protein expression analysis, and immunofluorescence.
• Maintain the laboratory's database and biobank of patient samples.
• Keep accurate and organized records and meet regularly with the principal investigator.
• Support daily laboratory operations, including inventory monitoring, ordering supplies, and general upkeep.
• Opportunity to develop an independent project as the position progresses.

Qualifications

Required:

• Bachelor's degree in a life‑sciences discipline.
• Extensive laboratory bench research experience during college or at least one year of full‑time research‑assistant employment.
• Tissue‑culture experience.
• Proficiency in standard molecular‑biology techniques, including western blotting, PCR, and DNA gel electrophoresis.
• Strong organizational skills and the ability to prioritize and manage multiple projects in a fast‑paced environment.
• Clear written and verbal communication, critical thinking, and the ability to work independently.
• Proficiency with Word, Excel, and PowerPoint, and a willingness to learn Adobe Acrobat, Adobe Illustrator, and Keynote.

Preferred:

• Master's degree in life sciences.
• Experience with making DNA and RNA libraries for sequencing.

Compensation

Compensation Range: $50,000 – $55,000 per year.