Research Assistant II Immunotherapy Platform

Within the Immunotherapy Platform at UT MD Anderson, this role supports critical laboratory and clinical research activities, contributing to translational research and clinical trial operations. The position applies technical expertise to plan and carry out laboratory and/or clinical research projects under the supervision of the research project manager.

About the role

The ideal candidate will have hands-on experience with assays routinely performed in the lab, including a strong foundation in basic molecular biology techniques such as RNA and DNA isolation, nucleic acid quantification and quality assessment, PCR, general sample processing, and cell culture. While experience in human T-cell and B-cell immunology is ideal, candidates with closely related research experience—particularly those proficient in cell culture and molecular biology—are encouraged to apply. The successful candidate will bring a strong technical foundation, a willingness to learn, and the ability to quickly adapt to new laboratory methods and technologies.

This role directly supports innovative immunotherapy and clinical research programs that advance cancer treatment and improve patient outcomes. Team members contribute to cutting-edge scientific discoveries while gaining exposure to advanced laboratory technologies, multidisciplinary collaboration, professional development opportunities, and a supportive work environment.

Responsibilities

• Tissue Culture
  • Collect tissue samples from UT MD Anderson north campus and process blood samples using Ficoll gradient methods
  • Process tumor samples through enzymatic digestion procedures
  • Prepare cells for immediate laboratory analysis and cryogenic storage
  • Maintain cell cultures for research assays
  • Observe and identify cellular changes using microscopy techniques
  • Determine cell counts and assess cell viability for research applications
• Laboratory Responsibilities
  • Perform multi-omic immune monitoring assays on clinical specimens
  • Conduct 10x single-cell sequencing assays, Visium/Cytassist assays, Bruker Nanostring CosMx and GeoMx assays
  • Perform Nanostring assays, nucleic acid purification, CyTOF analyses, ELISPOT assays, and multiplex cytokine/chemokine assays
  • Prepare sequencing libraries, pool libraries, and submit samples to the Genomics Core with associated probe information
  • Prepare sterile media, stock solutions, and laboratory reagents
  • Perform lymphocyte staining and flow cytometry phenotyping
  • Apply safety procedures when working with human samples, chemicals, hazardous materials, and laboratory glassware
  • Participate in meetings, assist with organization of scientific discussions, and present data as required
• Advanced Research & Sample Management
  • Operate basic laboratory equipment according to established procedures
  • Assist with CyTOF antibody conjugation activities and perform titration of metal-conjugated antibodies
  • Stain and run samples using the Helios platform when needed
  • Coordinate shipping and receiving of biological specimens in accordance with government compliance regulations
• Lab Maintenance
  • Maintain productive working relationships with laboratory team members
  • Explain current scientific protocols to staff members as needed and assist in training new laboratory personnel
  • Utilize and maintain laboratory equipment
  • Work late hours and weekends as operational needs require
  • Maintain an organized, current, and legible laboratory journal documenting experimental activities
  • Monitor laboratory inventory and maintain adequate stock levels of supplies
  • Perform other duties as assigned

Requirements

• Education
  • Required: Bachelor's degree with major coursework in one of the basic sciences
  • Preferred: Master's Degree in Basic Science
• Experience
  • Required: Two years' experience in scientific or experimental research work (no experience required with preferred degree)
  • Preferred: Experience in immunology-based research environments, specializing in human T-cell and B-cell studies, with a strong foundation in molecular biology and associated laboratory techniques

Benefits

• Employer-paid medical coverage starting day one for employees working 30+ hours/week, plus optional group dental, vision, life, AD&D, and disability insurance
• Accruals for PTO and Extended Illness Bank, plus paid holidays, wellness, childcare, and other leave options
• Tuition Assistance Program after six months of service and access to extensive wellness, fitness, and employee resource groups
• Defined-benefit pension through the Teachers Retirement System, voluntary retirement plans, and employer-paid life and reduced salary protection programs

Pay

• Minimum Salary: $45,000 USD
• Midpoint Salary: $56,500 USD
• Maximum Salary: $68,000 USD

Schedule

• Full-Time, Regular
• Day/Evening shifts, including weekends as needed
• Onsite

FLSA: Exempt and not eligible for overtime pay