Principal Scientist, Neuroscience / Genetic Medicine

Build our future together at Regeneron, where we use science and innovation to develop life-changing medicines for people with serious diseases. Join our Genetic Medicines team as a Principal Scientist to advance the preclinical development of targeted genetic medicines for central nervous system disorders.

About the role

In this role, you will design and lead experiments across CNS disease models, working as part of a collaborative, multidisciplinary team spanning platform technology, disease biology, and early clinical development. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

Responsibilities

• Design experiments to evaluate the efficacy, target engagement, and delivery efficiency of viral and non-viral therapeutic candidates across CNS disease models
• Design AAV transgene cassettes to optimize therapeutic efficacy
• Lead a team of associates in the execution of experiments and analysis of primary data
• Interpret complex datasets, integrating findings with current scientific literature to propose data-driven next steps
• Communicate project strategy, scientific vision, and data updates to senior leaders
• Author and review preclinical study reports to support regulatory submissions
• Approach scientific problems with an engineering mindset and a design-build-test-learn framework
• Coach and mentor junior scientists within a multidisciplinary team environment

Requirements

• Experience evaluating DNA- or RNA-based therapeutics in small-animal models
• Hands-on experience with molecular biology techniques
• Experience mentoring and managing research associates
• Excellent communication and presentation skills

Qualifications

• Preferred: Ph.D. in neuroscience, gene therapy, or a related discipline
• Preferred: 5+ years of combined postdoctoral and industry experience in biotechnology, genetic medicines, or CNS drug discovery
• Preferred: Knowledge of both viral and non-viral genetic medicine delivery modalities

Location

Tarrytown, NY (onsite)

Pay

Salary Range (annually): $128,600.00 - $210,000.00

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits, 401(k) company match
• Health and wellness programs, fitness centers
• Insurance benefits (e.g., medical, dental, vision, life, and disability)
• Paid time off
• Family support benefits