Principal Scientist, Translational Medicine, Neuroscience

Responsibilities

• Collaborate with basic science teams on disease‑specific projects, providing clinical expertise to identify and validate novel targets, and design pre‑clinical and clinical experiments for therapeutic development.
• Partner with cross‑functional groups—including discovery scientists, pharmacologists, toxicologists, and other specialists—to advance novel therapeutics from pre‑clinical to clinical development.
• Lead early‑development teams, working closely with internal and external scientists (discovery research, biostatistics, drug metabolism, modeling & simulation, regulatory affairs, global clinical‑trials operations) to design and execute early clinical development strategies.
• Take a lead role in developing and executing clinical pharmacology studies across all phases (I‑IV), including formulation/device changes, drug‑drug interaction studies, and studies in special populations.
• Provide early‑phase clinical pharmacology support through regulatory filing processes, preparing supporting documents and presentations.
• Develop and execute studies to validate established and novel clinical biomarkers (blood/tissue sampling, imaging, electrophysiology, wearable devices, behavioral responses) to assess biological activity in humans.
• Offer clinical and scientific expertise to evaluate internal and external partnership opportunities.
• Engage with the broader scientific community—consulting academic thought leaders, preparing posters/publications, and presenting at conferences.
• Work broadly with key functions across the company at research sites worldwide.
• Contribute to target identification by partnering with Discovery Sciences to bring a clinical perspective to early target validation and execute clinical studies that justify full development.
• Lead early clinical development strategy from pre‑clinical stage through Phase 1 safety/tolerability/PK/PD studies, Phase 2 proof‑of‑concept, and enable Phase 3 trials.
• Develop biomarker strategies through cross‑functional teams to advance therapeutics from First‑in‑Human studies through clinical proof‑of‑concept, including experimental‑medicine studies.
• Develop and execute clinical pharmacology strategies to support later‑stage development and worldwide regulatory submissions.

Education

Doctoral degree: MD or MD/PhD (or international equivalent) required.

Experience

• Demonstrated record of scientific scholarship and achievement in biomedical research, including peer‑reviewed publications.
• Clinical medicine experience with completion or anticipated completion of residency training.
• Board certification or eligibility in Neurology, Psychiatry, or a related discipline involving neurologic/psychiatric diseases (preferred).
• Academic faculty experience (preferred).
• Prior translational research and/or early clinical development experience (helpful but not required).

Required Skills

• Biomedical research
• Clinical development
• Clinical medicine
• Clinical research
• Clinical trial planning
• Cross‑functional teamwork
• Neuroscience research
• Neurologic disorders
• Translational research

Preferred Skills

• Early clinical development
• Neurodegenerative diseases
• Neurological disorders
• Neuroscience
• Translational medicine

Pay

Salary range: $255,800 – $402,700 per year. The successful candidate will be eligible for an annual bonus and long‑term incentive, if applicable.

Benefits

• Medical, dental, vision, and other healthcare insurance for employee and family.
• Retirement benefits, including a 401(k) plan.
• Paid holidays, vacation, compassionate leave, and sick days.
• Comprehensive benefits package detailed at the company’s compensation and benefits website.