Principal Scientist I/II, Oligonucleotide Chemistry & Innovation

Location: Cambridge, USA | Relocation support available

About the Role

Imagine advancing the next generation of RNA therapeutics that have the potential to transform patients’ lives around the world. As a Principal Scientist I or II in Oligonucleotide Chemistry and Innovation, you will play a critical role in building and advancing Novartis’ xRNA therapeutic platform. You will bring scientific creativity, technical expertise, and innovation to the forefront of drug discovery, working alongside a collaborative team of world-class scientists. This role involves leading the development of novel oligonucleotide chemistries, driving therapeutic innovation, and shaping the future of RNA medicines in a dynamic and fast-paced research environment. This is an exciting opportunity to make a meaningful scientific impact while mentoring others and contributing to breakthrough therapies that could redefine possibilities for patients.

Responsibilities

• Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides and conjugates.
• Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies.
• Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates.
• Drive cross-functional collaboration to advance oligonucleotide therapeutic programs from discovery through preclinical stages.
• Mentor scientists and enhance laboratory workflows to improve efficiency, quality, and innovation.
• Establish and maintain standard operating procedures supporting reproducible oligonucleotide manufacturing processes.
• Operate, troubleshoot, and maintain critical analytical and synthesis instrumentation, including high performance liquid chromatography and liquid chromatography mass spectrometry.

Requirements

• Doctor of Philosophy in Chemistry or a related scientific discipline.
• At least five years of experience synthesizing therapeutic oligonucleotides in an industry or research setting.
• Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification, and characterization.
• Proven experience developing and optimizing novel oligonucleotide chemistries and conjugates.
• Strong knowledge of phosphoramidite chemistry and modern synthetic chemistry techniques.
• Hands-on experience operating automated oligonucleotide synthesizers and analytical instrumentation.
• Demonstrated understanding of RNA therapeutics, including small interfering ribonucleic acid and antisense oligonucleotides.
• Excellent collaboration and communication skills with the ability to work across multidisciplinary teams.

Benefits

At Novartis, we’re committed to reimagining medicine together—and rewarding the people who make it happen. Our benefits include:

• Insurance plans and retirement plans.
• Wellbeing resources and global recognition programs.
• Flexible and hybrid working options, where possible.
• A minimum of 14 weeks paid parental leave.
• Performance-based bonus eligibility depending on certain performance parameters.

Pay

Expected annual base salary range for this role in the US: $108,500.00 - $201,500.00 USD. The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies, and experience. Upon joining Novartis, your salary will be reviewed periodically. Pay equity is a fundamental principle of our employment policy.