Principal Scientist (Director), Anatomic Pathologist

About the role

The Translational Pathology group within the TMB organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) to join our innovative team. This position plays a crucial role in supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company's clinical therapeutic pipeline.

Responsibilities

• Establish new histopathology-based assays in the laboratory as part of a team.
• Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company's therapeutics.
• Collaborate in the development and analytic validation of digital pathology algorithms.
• Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials.
• Provide subject matter expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders.

Qualifications

• Education: Minimum Requirement: Doctor of Medicine (MD or equivalent) or MD/PhD with specialized training in Anatomic Pathology.
• Experience and Skills:
  • Post-residency training experience of 1-3 years, including experience in biological research and the ability to work effectively in multidisciplinary teams.
  • Proficient in general anatomic pathology diagnosis and routine histopathology testing, including immunohistochemistry (IHC), cytogenetics (in-situ hybridization), sample quality and testing procedures, and applicable laboratory testing regulations.
  • Excellent oral and written skills with a proven record of scientific contributions to the scientific community.
  • Demonstrated ability to lead and manage projects in a fast-paced environment.
  • Able to interact well with groups and maintain strong working relationships with internal and external collaborators.
  • Strong understanding of clinical laboratory regulatory standards and GxP compliant workflows.
  • Strong understanding of disease processes and pathways relevant to our company's therapeutics.

Preferred Qualifications

• Experience and Skills:
  • Experience with the development and analytic validation of digital or computational pathology algorithms strongly preferred.
  • Experience working in the diagnostic or pharmaceutical industry.
  • Broad knowledge of the drug development process and translational medicine.
  • Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
  • Experience with multiplex tissue-based spatial profiling assays (i.e., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry, spatial transcriptomics).
  • Familiarity with clinical grade whole slide imaging platforms (i.e., Leica Aperio, Hamamatsu, Roche DP 600).
  • Proficiency in commercial or open-source image analysis software packages (i.e., Visiopharm, HALO, QuPath).
  • Knowledge of using statistical software packages (i.e., Prism, SPSS).
  • Understanding of regulated clinical bioanalysis.