Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)

Key Responsibilities

• Design, execute, and analyze results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
• Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
• Partner closely with other functional teams for better understanding of MOA and fundamental immunology.

Requirements

• Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies.
• Experience with cell therapy a plus but not required.
• A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs.
• Deep understanding of immunology, particularly T cell biology highly desirable.
• Hematology Expertise: Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
• Experience working with multiple dimensional data, extract biological insights from data highly desirable.
• Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.