Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology

We need to output HTML fragment with sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. Only include sections that have real specific content. We must not repeat job title. Must not include Job ID etc. Must preserve all substantive info. Remove boilerplate like EEO, accommodation, etc. Must not include application instructions, etc. Must not include duplicated lines. Must not include Pay/Schedule/Benefits unless posting actually states them. The posting includes salary range, benefits description, travel requirements, flexible work arrangements, relocation, visa sponsorship, etc. So we have Pay (salary range), Benefits (list of benefits), Schedule (maybe travel requirements, flexible work arrangements, shift). Also there is "Relocation: Domestic VISA Sponsorship No Travel Requirements 10% Flexible Work Arrangements Hybrid Shift 1st - Day". That's schedule info. So we can include Schedule section. We need to use

for section headings. Use

• for any list of duties/requirements/benefits. Use

  for prose. We must not create sections with filler like "commensurate with experience". Not needed. We need to preserve all substantive information: The job description includes many responsibilities, qualifications, required experience and skills, preferred experience and skills, required skills list, preferred skills list, etc. Also includes "Education" under Qualifications. Also includes "Required Experience And Skills", "Preferred Experience And Skills". Also includes "Required Skills" list and "Preferred Skills" list. Also includes "Current Employees apply HERE ..." which is application instruction - must remove. Also includes "US And Puerto Rico Residents Only" - maybe not needed? It's a requirement? Might be considered eligibility but it's a location restriction. Might be considered substantive? It says US And Puerto Rico Residents Only. That's a requirement. Should we keep? It's not boilerplate? It's a specific eligibility. Probably keep as part of Requirements or Qualifications? Might be under Requirements. But we must not include application instructions. This is not instruction, it's a requirement. We'll keep. Also includes "As an Equal Employment Opportunity Employer..." which is EEO boilerplate - remove. Also includes "As a federal contractor..." remove. Also includes "We are proud to be a company..." maybe fluff but could be considered boilerplate? It's about inclusion; might be considered EEO/boilerplate. Safer to remove. Also includes "Learn more about your rights..." remove. Also includes "The salary range for this role is $190,800.00 - $300,300.00" - keep for Pay. Also includes "The successful candidate will be eligible for annual bonus and long-term incentive, if applicable." - keep under Benefits maybe. Also includes "We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days." - keep Benefits. Also includes "More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits." - that's a link, maybe keep as part of Benefits? It's a reference; could keep but it's not a list item. Might be okay as a p. Also includes "You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee)." - application instruction - remove. Also includes "The application deadline for this position is stated on this posting." - remove. Also includes "San Francisco Residents Only: ..." and "Los Angeles Residents Only: ..." - these are location-specific considerations; maybe keep as part of Requirements? Could be considered eligibility. Might keep as a note. Also includes "Search Firm Representatives Please Read Carefully ..." - remove. Also includes "Employee Status Regular Relocation: Domestic VISA Sponsorship No Travel Requirements 10% Flexible Work Arrangements Hybrid Shift 1st - Day Valid Driving License No Hazardous Material(s) N/A Job Posting End Date 10/9/2026 A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID:R417644" - remove job posting end date etc. But we might keep Relocation, VISA Sponsorship, Travel Requirements, Flexible Work Arrangements, Shift as schedule info. The rest (Employee Status Regular, Valid Driving License No, Hazardous Material(s) N/A) maybe not needed? Could be considered metadata but not required. We could drop them as they are not substantive? The instruction: "Do NOT put Job ID / requisition numbers as headings — fold minor metadata into a short

  or drop it." So we can drop minor metadata like Employee Status, Valid Driving License, Hazardous Material(s). Keep Relocation, VISA Sponsorship, Travel Requirements, Flexible Work Arrangements, Shift as schedule. Thus schedule section: maybe include bullet list: Relocation: Domestic; VISA Sponsorship: No; Travel Requirements: 10%; Flexible Work Arrangements: Hybrid; Shift: 1st - Day. Now we need to structure sections. We have About the role: The initial paragraph: "We are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Oncology and Hematology portfolios. This role will lead the design, execution, analysis, and communication of translational and clinical biomarker strategies across programs spanning early through late clinical development. The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, tumor or disease biology, pharmacodynamics, molecular heterogeneity, patient selection, response and resistance, dose and regimen selection, and clinical endpoints. Biomarker plans should focus on generating high-value, interpretable evidence that informs program decisions rather than data generation alone." That's About the role. Responsibilities: The list under "Key Responsibilities" with many bullet points. We'll convert each bullet to

• . Qualifications: Education: Ph.D., M.D., or equivalent advanced scientific degree with relevant experience in oncology, hematology, translational medicine, biomarker science, drug development, or a related discipline. Also maybe include "Required Experience And Skills" and "Preferred Experience And Skills" could be under Requirements? Actually the spec says sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. So we need to map content. We have Qualifications (education). Requirements (maybe required experience and skills). Skills (maybe required skills list and preferred skills list). But we also have "Required Experience And Skills" and "Preferred Experience And Skills". Could treat those as Requirements (required) and maybe also under Skills? However we have separate Skills section for required and preferred skills lists. Let's decide: - Requirements: include Required Experience And Skills (the paragraph list of bullet-like items). Also maybe include "US And Puerto Rico Residents Only" and location-specific notes. - Qualifications: include Education paragraph. - Skills: include Required Skills list and Preferred Skills list (maybe as two sublists). Could also include "Preferred Experience And Skills" as part of Skills? But we already have Preferred Experience And Skills separate; maybe we can merge into Skills as well. However to avoid duplication, we could put Preferred Experience And Skills under Skills as well. But the spec says we should not create thin sections; we can combine. Better: Requirements: Required Experience And Skills (the bullet-like items). Qualifications: Education. Skills: combine Required Skills list, Preferred Skills list, and Preferred Experience And Skills (maybe as additional bullet items). But we need to avoid too many sections; we can have Skills section with two subheadings? Not allowed; only

  for section headings. Inside Skills we can have

  paragraphs and

  • lists. We could have two lists: Required Skills and Preferred Skills. Also we could include Preferred Experience And Skills as another list maybe under Skills as well. But we must not invent sections; we can have multiple
    inside Skills. Now Benefits: list of benefits. Pay: salary range. Schedule: relocation, visa sponsorship, travel requirements, flexible work arrangements, shift. Now we need to ensure we don't repeat content. Let's extract. Responsibilities bullets (from "Key Responsibilities"): - Develop and lead integrated biomarker strategies across oncology and hematology programs, in partnership with cross-functional development teams. - Translate disease biology and therapeutic mechanism into clear translational hypotheses and fit-for-purpose biomarker approaches. - Define how biomarkers can inform key development questions including proof of biology, target engagement, dose and regimen selection, patient selection, response assessment, resistance mechanisms, and go/no-go decisions. - Ensure biomarker strategies are focused and scalable, with clear linkage between the development question, proposed measurement, expected result, and potential action. - Serve as the biomarker representative on cross-functional program teams and provide strategic biomarker input to program-level decision making. - Partner closely with Discovery, Clinical Development, Quantitative Sciences, Regulatory, Data Science, Clinical Operations, Pathology, Diagnostics, and other functions to develop integrated translational strategies. - Lead interpretation of biomarker and clinical datasets and translate complex findings into clear, actionable recommendations. - Develop approaches to characterize disease heterogeneity, molecular drivers, treatment response, mechanisms of resistance, and biological determinants of clinical outcome. - Develop and evaluate patient-selection and precision-medicine strategies, including approaches based on genomic, transcriptomic, protein-expression, cellular, or other disease-specific biomarkers. - Apply circulating and tissue-based biomarker approaches, as appropriate, including ctDNA, minimal residual disease, molecular profiling, immunophenotyping, and pharmacodynamic biomarkers. - For hematologic malignancies, develop strategies incorporating disease-relevant measures such as molecular response, measurable residual disease, clonal evolution, mutational burden, lineage or cellular phenotype, and resistance-associated alterations, as appropriate to the program. - For solid tumors, develop strategies addressing target expression, tumor biology, molecular subtype, immune contexture, circulating biomarkers, mechanisms of response and resistance, and potential predictive biomarkers. - Evaluate emerging biomarker technologies and analytical approaches based on their ability to address meaningful development questions and influence program decisions. - Contribute to biomarker strategies supporting potential companion diagnostic or regulatory biomarker development, where appropriate. - Communicate biomarker strategies, results, risks, and recommendations clearly to cross-functional teams, governance groups, and key stakeholders. - Provide scientific guidance and mentorship to biomarker scientists and contribute to a collaborative, strategically focused biomarker organization. - Support publications, scientific presentations, external collaborations, and interactions with key external experts as appropriate. Now Required Experience And Skills bullet-like items (the paragraph after "Required Experience And Skills"): It says: "Significant experience developing and executing translational or clinical biomarker strategies in oncology or hematology drug development. Strong scientific expertise in cancer biology, hematologic malignancies, translational oncology, or a related discipline. Demonstrated ability to translate scientific hypotheses into biomarker strategies that inform clinical development decisions. Strong understanding of the relationship between mechanism of action, disease biology, molecular heterogeneity, pharmacology, biomarkers, clinical endpoints, and development strategy. Experience with one or more relevant biomarker modalities, such as NGS, ctDNA, MRD, immunohistochemistry, flow cytometry, gene-expression profiling, proteomics, or other molecular and cellular approaches. Ability to lead cross-functional scientific work in a matrixed environment and influence without direct authority. Strong analytical and problem-solving skills, including the ability to synthesize complex and multidimensional datasets into clear, decision-oriented conclusions. Ability to prioritize high-value, decision-enabling biomarker work and distinguish it from lower-priority exploratory activities. Excellent written and verbal communication skills and the ability to communicate scientific strategy to stakeholders. Working knowledge of biostatistics, bioinformatics, quantitative sciences, and multidimensional biomarker data analysis. Strategic mindset with a focus on scientific rigor, prioritization, scalability, and generation of actionable evidence." We'll turn each line into
    • . Preferred Experience And Skills bullet-like items: "Experience supporting oncology or hematology programs across multiple stages of clinical development. Experience with predictive, pharmacodynamic, prognostic, resistance, MRD, or precision-medicine biomarker strategies. Experience integrating tissue, blood, molecular, and cellular biomarker