Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)

Key Responsibilities

• Design, execute, and analyze results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Translational Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
• Understanding MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
• Cross-Functional Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology.

Requirements

• Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies.
• Experience with cell therapy a plus but not required.
• A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs.
• Deep understanding of immunology, particularly T cell biology highly desirable.
• Hematology Expertise: Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
• Experience working with multiple dimensional data, extract biological insights from data highly desirable.
• Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.

Benefits and Paid Time Off

Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.

Additional Voluntary Benefits

• Flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
• Voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.