Principal Scientist, Biologics Cell Line Development

About the role

We are seeking a Principal Scientist to join our Biologics Cell Line Development team in Boston, MA. This role is for a scientific innovator and a manager of junior scientists. The successful candidate will conduct and supervise CHO-based cell line development for biologic therapeutics moving into clinical development. Significant effort will be dedicated to designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology.

Responsibilities

• Perform CHO cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment.
• Drive innovation through the development of improved genetic components, host cell line engineering, and cell line development process optimization.
• Identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and continued innovation.
• Represent the cell line development team on cross-functional projects, making decisions for cell line activities and effectively communicating results, progress, and plans.
• Represent Asimov externally, contributing to industry conferences, industry forums, filing patents, and publishing peer-reviewed manuscripts.
• Manage and mentor a team of 3+ scientists focused on CHO-based biologics CLD, providing technical direction and supporting them in their professional development.

Requirements

Experience of 8+ years CHO-based cell line development is a must, stemming from expressing IgGs and bispecifics in an industrial CLD environment. A Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field is required. Minimum 1 year experience managing direct reports and providing technical guidance is preferred.

Qualifications

• Familiarity with vector optimization to improve titer and product quality attributes for complex bispecific scaffolds is a plus.
• Experience with CLD process optimization is a plus.
• Experience with development of automated high-throughput screening for CLD workflows is a plus.
• Experience working with a global customer base is a plus but not required.

Skills

You are a creative problem solver never satisfied with the status quo and get excited about the opportunity to drive the creation of disruptive technology.

Benefits

Compensation Range: $170K - $190K