Principal Clinical Scientist

About the Role

What if your years of clinical trial expertise could directly shape how AI reasons about medical evidence, regulatory submissions, and patient outcomes? We're looking for a Principal Clinical Scientist to bring senior-level rigor to cutting-edge AI research — ensuring the clinical data and analyses powering next-generation AI systems meet the standards expected in real-world regulatory environments.

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems
• Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance
• Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Work independently and asynchronously — fully on your own schedule

Who You Are

• Senior-level experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
• Strong background in clinical research methodology, biostatistics, or translational science
• Naturally detail-oriented with a systematic, rigorous approach to scientific evaluation
• Clear and precise written communicator comfortable providing structured, actionable feedback

Nice to Have

• Prior experience with data annotation, data quality assurance, or evaluation systems
• Familiarity with AI tools or machine learning workflows in clinical or biomedical contexts
• Background in pharmacovigilance, medical affairs, or health technology assessment
• Experience working across multiple therapeutic areas or global regulatory jurisdictions

Why Join Us

• Work directly on frontier AI systems making a real impact on clinical and biomedical research
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, high-stakes scientific work
• Influence how AI understands, evaluates, and communicates real-world clinical evidence
• Collaborate with leading AI research teams and labs at the cutting edge of the field
• Potential for ongoing work and contract extension as new projects launch

Organization

Alignerr

Type

Hourly Contract

Location

Remote

Commitment

10–40 hours/week