Principal Clinical Scientist

About the Role

What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — helping ensure these models reason about clinical evidence the way a seasoned scientist would.

This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required — just deep clinical expertise and a sharp eye for scientific rigor.

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations
• Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes
• Flag gaps in methodology, data quality, or regulatory relevance across AI-generated clinical content

Who You Are

• Senior-level clinical researcher with hands-on experience designing trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Naturally rigorous — you hold AI-generated outputs to the same standard you'd apply in a real submission
• Self-directed and comfortable working independently in an asynchronous environment

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI output assessment
• Background in pharmacology, oncology, rare disease, or another specialized therapeutic area
• Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks
• Experience working across multidisciplinary research teams

Why Join Us

• Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted
• Influence how AI understands and evaluates real-world clinical evidence — at a scale no individual trial could achieve
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, high-impact, task-based work
• Collaborate with world-leading AI research labs on problems that matter
• Potential for ongoing work and contract extension as new projects launch

Organization

Organization: Alignerr

Type

Type: Hourly Contract

Location

Location: Remote

Commitment

Commitment: 10–40 hours/week