Pri Sci/Sr Pri Sci/Assoc Director - In Vivo Pharmacology

About the role

We are seeking an experienced pharmacologist to design and manage in vivo studies that advance our programs toward clinical candidates. This role will work closely with biologists, medicinal and computational chemists, and external CRO partners to build and execute our pharmacology and translational strategy.

Responsibilities

• Serve as the in vivo pharmacology lead for several drug discovery projects.
• Establish in vivo strategy and study plans.
• Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
• Design, manage, and interpret in vivo pharmacology studies—including PK/PD, efficacy, and tolerability—to advance programs toward development candidates.
• Select, develop, and validate disease-relevant animal models.
• Manage internal and external in vivo work, overseeing study quality, timelines, data integrity, and budget across multiple programs.
• Collaborate with chemistry and biology teams to integrate pharmacology, PK, and biomarker data to drive compound optimization across potency, selectivity, exposure, and safety.
• Oversee animal welfare and regulatory compliance, including IACUC protocol design and adherence to applicable in vivo study guidelines.
• Prepare and present study designs and data to internal teams and external partners, contribute to Think Bioscience's overall pharmacology and translational strategy, and contribute to nonclinical study reports supporting IND filings.

Qualifications

• Ph.D. in pharmacology, physiology, biology, or a related discipline, with 5+ years of experience designing and managing in vivo studies in biotech or pharma (title and level commensurate with experience).
• Demonstrated expertise designing, executing, and interpreting in vivo pharmacology studies (PK/PD, efficacy, tolerability, biomarker) and translating results into program decisions.
• Experience with disease-relevant animal models in rare and/or multisystem diseases—RASopathies or other genetically defined disorders strongly preferred.
• Familiarity with DMPK principles (clearance, oral bioavailability, exposure-response relationships) and ability to integrate PK/PD data into compound optimization decisions.
• Expertise in oncology/immuno-oncology models or demonstrated adaptability across multiple therapeutic areas.
• Experience managing external CROs and collaborating across chemistry, biology, and DMPK teams; working knowledge of IACUC processes and animal welfare standards.
• Excellent oral and written communication skills, with the ability to present complex data to internal teams and external partners.
• Demonstrated productivity through patents, publications, and/or contributions to development candidates.

What We Offer

• Collaborative environment for innovative science and a mission-driven company.
• Opportunity for technical expansion and professional growth.
• Influence key decisions in a fast-growing startup.
• Equity participation in a well-capitalized company with differentiated platform technology and a first-in-class pipeline.
• Competitive compensation and benefits package, including a salary range of $120,000-180,000 per year (title and salary commensurate with experience).