Postdoctoral Researcher - Cell Biology, Neurobiology and Anatomy

We seek a highly motivated postdoctoral research fellow to lead studies in one or more of our key research areas:

• The role of astrocytes in motor neuron pathology in spinal muscular atrophy
• Mechanisms underlying neural progenitor cell disruption following cytomegalovirus infection

The lab employs a variety of approaches, including:

• Generating and differentiating patient-derived induced pluripotent stem cells into neuronal and glial subtypes and forebrain organoids
• Live cell calcium imaging and microelectrode array
• Fluorescent microscopy
• Viral gene delivery for overexpression and knockdown studies (in vitro and in vivo)
• Cell surface proteomics and RNA sequencing

Translational projects are available, and collaboration with clinicians from major adjacent hospitals is a regular part of the role. Our team is interactive, with multiple ongoing collaborations across departments at MCW and other institutes.

Responsibilities

• Independently design, execute, and analyze complex research procedures using induced pluripotent stem cell-derived neurons, astrocytes, microglia, and forebrain organoids
• Perform calcium imaging on neurons and astrocytes
• Bring new molecular and/or physiological methods to the laboratory
• Develop creative methodologies for lab procedures, including high-content imaging, cell surface proteomics, and RNA sequencing approaches and analysis
• Teach and guide technicians, rotating graduate and medical students, and junior graduate students in cellular and molecular analyses, including experiment organization and data analysis
• Participate in lab meetings, evaluate and interpret data, develop methodologies, and assess lab procedures
• May oversee laboratory personnel, including training, development, and daily work direction
• Act as an engaged team member, contributing to lab and department outings
• Independently write first drafts of research proposals and first-author manuscripts
• Present scientific findings at local, national, and international meetings
• Apply for competitive independent funding opportunities
• Communicate effectively with lab members via email and in-person interactions
• Provide feedback on grants and manuscripts for other lab members and the principal investigator
• Perform other duties as assigned

Requirements

• Strong motivation, team-player attitude, and ability to design, organize, and coordinate scientific research projects
• Previous laboratory experience, including sound scientific practice, methodology development, and accurate laboratory techniques
• Ability to read, understand, follow, and enforce safety procedures
• Experience with scientific approaches in neuroscience, induced pluripotent stem cell disease modeling, neurodegeneration, and molecular biology is preferred
• Experience with mouse models is desirable

Qualifications

• Minimum Required Education: PhD in a scientific field
• Minimum Required Experience: 0 years
• Preferred Education: Neuroscience, Cell and Developmental Biology
• Preferred Experience: Progressive knowledge and skill development in stem cell biology

Physical Requirements

• Occasionally lift moderate-weight materials
• Standing or walking continuously

Work Environment

• Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids
• Work is performed in an environmentally controlled laboratory setting

Sensory Acuity

• Ability to detect and translate speech or other communication
• May occasionally require the ability to distinguish colors and perceive relative distances between objects

Benefits

• Outstanding healthcare coverage (Health, Vision, and Dental) with flexible spending options
• 403B Retirement Package
• Competitive vacation and paid holidays
• Tuition reimbursement
• Paid parental leave
• Employee & Family Assistance Program (EFAP)
• Pet insurance
• On-campus fitness facility with classes
• Discounted rates on select cell phone plans, local fitness facilities, and Milwaukee recreation/entertainment