Postdoctoral Research Associate - Host Microbe Interactions

About the role

The Moreno lab investigates the emergence and evolution of bacterial pathogens. Our major research interests include elucidating the molecular strategies that bacterial pathogens develop for host colonization, virulence regulation and dispersal from the host. The O’Reilly lab investigates the structure of the proteome in cells with structural proteomics approaches. Our research program focuses on pathogenic members of the family Vibrionaceae with a strong emphasis on the intestinal pathogen Vibrio cholerae and the climate-sensitive pathogen Vibrio vulnificus, source of fulminant septicemia.

Responsibilities

• Lead research projects aimed at uncovering the structural organization of macromolecular complexes in cells using advanced crosslinking mass spectrometry, cryo-EM, and computational modeling.
• Design and execute experiments, analyze large-scale proteomic data, and interpret results.
• Contribute to the development of novel projects and proposals.
• Collaborate with microbiologists, structural biologists, computational modelers, and chemical biologists both within the lab, across the institution and with external collaborators.

Requirements

• Ph.D. in Biochemistry, Structural Biology, Biophysics, Chemical Biology, or a related discipline.
• A strong foundation in molecular biology, mass spectrometry-based proteomics, or chemical probe development.
• Prior experience with protein complex analysis, crosslinking chemistry, or integrative modeling is advantageous but not required.
• A demonstrated record of scientific productivity, critical thinking, and collaborative research is essential.

Qualifications

• Strong background in proteomics, protein biochemistry, molecular biology, or structural biology.
• Extensive experience with bacteriology, advanced molecular microbiology techniques.
• Demonstrated ability to design and execute experiments independently and to critically analyze data.
• Excellent written and verbal communication skills, with the ability to contribute to manuscripts, presentations, and collaborative discussions.
• Commitment to scientific rigor, integrity, and teamwork in a multidisciplinary environment.

Skills and Knowledge

• Experience in mass spectrometry–based proteomics, crosslinking chemistry, or structural methods such as cryo-EM or integrative modeling.
• Familiarity with computational tools for protein structure analysis, molecular modeling, or large-scale data interpretation.
• Prior exposure to cell biology or in situ biochemical methods.
• Ability to mentor junior researchers and contribute to collaborative, multi-lab projects.
• Enthusiasm for learning new experimental and computational approaches to explore macromolecular assemblies in their native context.

Benefits

Includes access to top-quality scientists and mentors, experience specifically designed programs to enhance professional growth and career readiness, customized professional and career growth, and competitive compensation starting at $72,500 a year, comprehensive benefits and generous relocation assistance.

Pay

$72,500 a year

Schedule

Full-time