Postdoctoral Position in Skeletal Regeneration, Diabetes, and Spatial Biology
University of Pennsylvania · Erie-Meadville Area · Yesterday
AnalystFull-time
About the role
The postdoctoral position is available in the laboratory of Dr. Dana Graves at the University of Pennsylvania's School of Dental Medicine, Department of Periodontics.
Responsibilities
- Define how diabetes-induced FOXO1 activity alters ciliogenesis, cellular differentiation, and regenerative signaling in chondrocytes and osteoblasts.
- Integrate conditional mouse models targeting FOXO1, IFT80, and combined FOXO1/IFT80 deletion with fracture-healing models of type 1 and type 2 diabetes to establish the cellular and molecular events that impair skeletal regeneration.
- Examine the effects of a newly developed IGF-1 mimetic-containing nanofiber hydrogel on inflammation and the sequential formation of immature mesenchymal tissue, cartilage, and bone, and determine whether the hydrogel restores cilia-dependent regenerative signaling, limits pathological FOXO1 activity, and improves structural and functional fracture healing in type 1 and type 2 diabetes.
Requirements
- Hold a PhD, MD, DMD, DVM, or equivalent degree in skeletal biology, cell biology, molecular biology, bioengineering, diabetes biology, immunology, computational biology, or a related field.
- Experience in one or more of the following areas is desirable: mouse genetics and disease models, bone or cartilage biology, fracture healing, spatial transcriptomics, single-cell RNA sequencing, computational analysis using R and Seurat, image analysis, molecular and cellular assays, histology, or microcomputed tomography.
Qualifications
- Evidence of scientific rigor, clear communication, and the ability to work both independently and collaboratively will be important.
Skills
- Strong experimental backgrounds are preferred.
Benefits
- Funding duration: The position is grant supported through 2028 and the PI has other grant support through 2031.
- Anticipated start date: Available immediately following interviews and feedback from references.
Pay
N/A
Schedule
N/A