Postdoctoral Position in RNA Biology and Intestinal Inflammation

Posted on: September 16, 2026 | Arbibe Lab | Institut Necker Enfants Malades (INEM), Inserm, Université Paris Cité | Paris, France

About the role

The Arbibe Laboratory at Institut Necker Enfants Malades is seeking a motivated Postdoctoral Research Fellow to investigate the role of non‑canonical RNA species, including double‑stranded RNAs (dsRNAs) and circular RNAs (circRNAs), in intestinal inflammation and epithelial repair in inflammatory bowel disease (IBD). The project lies at the interface of RNA biology, intestinal epithelial biology and inflammation, and will combine molecular approaches with intestinal organoids, mouse models and human IBD samples. The position is part of an ANR‑funded consortium project, will start in February 2027, and is funded for 3 years. Work Environment: Our laboratory is part of the Institut Necker Enfants Malades (INEM, Inserm U1151/CNRS UMR8253), located on the Necker‑Enfants Malades hospital campus in central Paris. INEM provides a collaborative environment bringing together fundamental and clinical research, with access to state‑of‑the‑art core facilities in genomics, imaging, flow cytometry, animal experimentation and organoid culture. The postdoctoral researcher will interact closely with scientists and clinicians at INEM and with the broader Paris biomedical research community, including Université Paris Cité, Institut Pasteur and Sorbonne Université.

Responsibilities

• Investigate the role of dsRNAs and circRNAs in intestinal inflammation and epithelial repair.
• Apply molecular biology techniques (RIP‑seq, CLIP/eCLIP‑seq, epitranscriptomic approaches) to study RNA‑protein and RNA interactions.
• Work with intestinal organoids, mouse models and human IBD samples.
• Conduct independent research and contribute to the ANR‑funded consortium project.

Qualifications

• PhD or equivalent degree in RNA biology, molecular biology, cell biology, immunology or a related discipline.
• Must have defended PhD within the last 2 years at the time of application.

Skills

• Strong molecular and cellular biology skills.
• Demonstrated ability to conduct independent research.
• Strong interest in RNA regulation and mechanisms of mucosal and inflammatory disease.
• Preferred: hands‑on experience with RIP‑seq, CLIP/eCLIP‑seq or related RNA‑protein/RNA interaction mapping.
• Preferred: epitranscriptomic approaches.
• Preferred: dsRNA and/or circular RNA biology.
• Advantage: experience with mouse models and/or intestinal organoid culture.