Postdoctoral Fellow or Associate Staff Scientist (Peters) Liver Fibrosis

The user wants me to reformat a job posting into clean, well-structured semantic HTML. Let me analyze the content and apply the rules. First, I need to identify the sections. The posting has: - Primary location, department, shift, schedule, hours, FTE, employee status (metadata) - About the lab/research (Alexander Miethke's Lab) - Specific goals for the applicant - Ideal candidate qualifications - Job Responsibilities (with sub-sections: Conduct Research/Lab Administration, Research Standards, Publish, Leadership, Financial Responsibility/Contribution to Grants, Teamwork) - Job Qualifications (PhD or MD, 7+ years experience) - About Us (Cincinnati Children's info) - EEO statement (boilerplate to remove) Rules: - Use

for section headings (About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule) - Use

• for lists,

  for prose - Do NOT repeat job title as heading (page already shows it) - Do NOT put Job ID/requisition numbers as headings — fold minor metadata into short

  or drop - Preserve ALL substantive information; do NOT invent or summarize away detail - Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, application instructions - Include a section ONLY when posting has real, specific content for it — never emit heading followed by filler/placeholder text (e.g., "commensurate with experience", "not specified", "N/A", "varies", "TBD") - Never create Pay/Schedule/Benefits sections unless posting actually states them - Prefer a few substantive sections over many thin ones - Output ONLY HTML fragment — no /, no markdown code fences Now, let's structure: The metadata at top: Primary Location, Department, Shift, Schedule, Weekly Hours, FTE, Employee Status. This is minor metadata. I'll fold into a short

  at the beginning or maybe under a "Position Details" heading? But rule says do not put Job ID/requisition numbers as headings — fold minor metadata into a short

  or drop it. So I'll include a brief paragraph with these details. Then "About the role" or "About the Lab" — the posting describes the lab and research focus. That's substantive. Specific goals for the applicant — that's part of the role description. Ideal candidate qualifications — that's requirements/qualifications. Job Responsibilities — detailed with sub-sections. I'll make a Responsibilities section with sub-headings? But rule says use

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  for main sections only. For sub-sections within Responsibilities, I could use

  or just incorporate into list items. But the content is detailed prose. I'll keep Responsibilities as one section with sub-headings as

  ? The instruction says "use

  for section headings". It doesn't say not to use other headings. But to follow the spirit, I'll use

  for main sections only. For sub-sections, I'll use or just paragraphs. Better: The responsibilities are grouped into categories: Conduct Research/Lab Administration, Research Standards, Publish, Leadership, Financial Responsibility/Contribution to Grants, Teamwork. These are essentially bullet points. I'll make a Responsibilities section with an unordered list where each list item contains the category title and description. Similarly, Qualifications: PhD or MD, 7+ years experience. That's a list. About Us: That's boilerplate about the institution. Could be included as "About the Organization" but it's somewhat generic. However, it's specific to Cincinnati Children's and includes recognitions. Might keep as a section. EEO statement: remove. No Pay, Benefits, Schedule sections because not specified (schedule is mentioned as Full time, Day shift, but that's in metadata). The posting doesn't have explicit pay or benefits details. So omit those sections. Now, let's craft HTML. Start with a paragraph for metadata:

  Location: Cincinnati, OH (Primary Location); Department: Gastroenterology; Shift: Day; Schedule: Full time; Weekly Hours: 40; FTE: 1; Employee Status: Regular

  Then sections:

  About the Role

  Alexander Miethke’s Lab in the Division of Gastroenterology has an immediate opening for a Postdoctoral Research Fellow or Associate Staff Scientist to study mechanisms driving immune mediated liver injury, bile duct damage and liver fibrosis in pediatric autoimmune liver disease. Dr. Miethke’s research focuses on discovering immune pathways controlling hepatobiliary injury in primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) to ultimately develop novel therapies. The laboratory uses established mouse models for sclerosing cholangitis, and several knockout and transgenic mice to discern disease mechanisms in pre‑clinical models and works closely with the Center for Autoimmune Liver Disease. Dr. Miethke collaborates with Dr. Wang, computational biologist in the division, and with Dr. Peters who studies mechanisms of liver allograft rejection and tolerance.

  The specific goals for the successful applicant are:

  • Refine iPSC‑derived cellular co‑culture and multicellular organoid systems to recapitulate liver tissue single‑cell RNA‑seq predictions on cellular cross‑talks driving liver cell injury and biliary fibrosis in PSC and AIH.
  • Develop animal models of large duct PSC.
  • Prepare high‑quality single‑cell and single‑nuclear preparations from cryopreserved liver (allograft) tissue samples for single‑cell RNA/ATAC‑seq.

  Requirements

  • PhD or MD (or equivalent) in biomedical research.
  • 7+ years of post‑doctoral or work experience in a similar discipline.
  • Experience in basic molecular techniques including gene expression quantification (RT‑PCR), protein analysis (ELISA, Western blot), immunohistochemistry, high‑parameter flow cytometry, cell‑culture techniques with iPSC‑derived and transformed cell lines, and established procedures for mouse model systems.
  • Strong background in bioinformatics and mouse/human immunology is encouraged.
  • Experience with analysis of RNA‑seq data and multi‑parameter flow cytometry is preferred.

  Responsibilities

  • Conduct Research / Lab Administration: Plans, directs and executes scientific research and laboratory experiments. Investigates feasibility of applying scientific principles to solve problems. Works on complex problems requiring in‑depth evaluation of various factors, applying broad knowledge of principles, theories and standard scientific/research protocols. Uses professional concepts to solve complex problems creatively and effectively. Exercises judgment within broadly defined practices in selecting methods, techniques and evaluation criteria. Responsible for lab administration (IRB/IACUC/biosafety). May oversee divisional or institutional core facilities, managing and/or providing training for instrumentation. Researches and improves current methods and evaluates innovative techniques. Designs and performs experiments and records data according to research protocol. Independently reproduces, evaluates, researches, and improves techniques currently used. Adapts new methods to existing procedures and modifies current experiments through scientific knowledge and intuition.
  • Research Standards: Maintains accurate and detailed records of all laboratory work and experiments. Develops, sets up and verifies new procedures in the laboratory. Standardizes and establishes new published procedures; evaluates innovative techniques. Develops new assays and protocols; designs formats. Discusses relevant insights about experimental results with Director and provides useful recommendations and analysis. Troubleshoots and corrects erroneous results or problems with laboratory equipment. Maintains and repairs equipment; monitors proper use by personnel. Maintains optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Demonstrates performance, consistency, accuracy, attention to detail, achieving expected results and continuous improvement.
  • Publish: Demonstrates continued productivity with multiple publications (minimum 10 as an example of the volume expected; impact matters). Drafts, writes and edits scientific reports, papers, journal articles and abstracts. Presents at local, national and international scientific meetings. Assists PI to review papers for journals. Has written multiple co‑authorships, or a first‑author or co‑senior‑author paper.
  • Leadership: Provides guidance to junior lab members and trainees, serves as contact for resolution of complex issues, provides education, guidance and work direction. May supervise junior staff. May provide input and feedback to managers on hiring decisions, professional development and performance management. Leads research programs or research teams within a lab and serves as leader of divisional cores. May act as spokesperson on research and assist in determining methods and procedures on new assignments. Participates in teaching, lectures and lab classes. Advises PI and other stakeholders as needed.
  • Financial Responsibility / Contribution to Grants: Contributes to grant writing and applications. Assists in preparing, writing and maintaining fiscal budget. Monitors expenditures and prepares capital expenditure requests. Prepares, approves and initiates check requests; tracks funding, maintains accurate balance and resolves discrepancies.
  • Teamwork: Trains and supervises the work of other laboratory personnel as appropriate. Maintains an integral role in the laboratory's meetings, presentations and publications. Presents information on research and laboratory work at laboratory meetings, journal clubs and seminars. Demonstrates attendance and punctuality, ability to work independently, initiative and dedication. Demonstrated success in technical proficiency, scientific creativity, collaboration and independent thought. Productivity measured by continued authorship on papers (first authorship weighted more heavily). Increased contribution to grants. Increased responsibility in division and lab management, leadership within the lab, divisional responsibility. Makes important contributions to scientific literature and conferences.

  About Cincinnati Children’s

  At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose.

  • Recognized by U.S. News & World Report as a top 10 best Children's Hospitals in the nation for more than 15 years.
  • Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding.
  • Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025).
  • One of the nation's America’s Most Innovative Companies as noted by Fortune.
  • Consistently certified as a great place to work.
  • A Leading Disability Employer as noted by the National Organization on Disability.
  • Magnet® designated for the fourth consecutive time by