Postdoctoral Fellow – Lipotoxicity and Liver Inflammation Laboratory

About the role

The Lipotoxicity and Liver Inflammation Laboratory at Mayo Clinic seeks a highly motivated postdoctoral fellow with a strong background in liver pathobiology or vascular biology and immunology to join our team. The role will focus on investigating mechanisms of liver injury, inflammation, and vascular dysfunction in Metabolic Associated Steatohepatitis (MASH), lipotoxic endotheliopathy, mitochondrial dysfunction, and immune interactions.

Responsibilities

• Conduct independent and collaborative research to investigate mechanisms of liver injury, inflammation, and vascular dysfunction in MASH.
• Design and execute experiments using in vitro and in vivo models of lipotoxic liver disease.
• Perform advanced molecular and cellular biology techniques, including but not limited to plasmid cloning, gene expression analysis, protein assays, and cell signaling studies.
• Isolate and characterize primary liver cells, including intrahepatic leukocytes, hepatocytes and liver sinusoidal endothelial cells.
• Manage and perform rodent handling and interventions, including diet-induced MASH models and genetic or pharmacologic manipulations.
• Apply flow cytometry, immunohistochemistry, and immunofluorescence techniques to assess cell populations and pathological changes.
• Perform basic bioinformatic analysis (e.g., RNA-seq) and interpret complex datasets.
• Participate in manuscript preparation, presentations, and grant writing.

Qualifications

• Ph.D. in Physiology and biomedical engineering, biochemistry and Molecular Biology, Immunology, Vascular Biology, or related biomedical discipline.
• Demonstrated expertise in liver pathobiology and basic molecular and mechanistic techniques.
• Hands-on experience with animal handling, including approval and conduct of rodent studies.
• Proven ability with plasmid cloning, gene manipulation, and cell isolation procedures.
• C competence in basic bioinformatic data analysis (e.g., differential gene expression, pathway analysis).
• Solid background in immunology, particularly as related to inflammation and cellular crosstalk.
• Familiarity with vascular biology or endothelial cell function in organ pathology is highly desirable.

Preferred Skills

• Use of omics approaches to understand tissue zonation and cell interactions.
• Experience in studying intercellular signaling.
• Strong written and oral communication skills suitable for presentations and publications.

Exemption Status

Exempt

Compensation Detail

$67,282.95 - $78,711.15 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Holiday Schedule

Mayo Clinic follows the federal government’s holiday schedule.

International Assignment

No

Site Description

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about "EOE is the Law." Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

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