Postdoctoral Fellow on Gene- and Metabolism-Targeting Therapeutics

About the role

Postdoctoral positions are available in the lab of Dr. Jian Xu at the Department of Pathology and Center of Excellence for Leukemia Studies (CELS) at St. Jude Children’s Research Hospital to study the genetic, epigenetic and metabolic processes that control stem cell development, blood disorders, and childhood cancers.

Responsibilities

• Employ high-throughput epigenomics, metabolomics, single-cell multiomics, (epi)genome editing, and preclinical models to define disease-associated epigenetic and metabolic programs that control stem cell development and how these processes go awry in cancer progression.
• Utilize cutting-edge genomics, metabolomics, molecular biology, and bioinformatics platforms, including in-house LC-MS and GS-MS-based metabolomic platforms, Illumina sequencer, 10xGenomics single‑cell technologies, and flow cytometry.
• Contribute to a multidisciplinary, collaborative team environment.

Potential research projects:

• Identify and target metabolic and epigenetic vulnerabilities in blood cancers and therapy response
• Develop non‑coding RNA‑based nucleic acid therapeutics for inherited blood disorders
• Target disease‑associated metabolic processes using pharmacologic and genetic approaches
• Develop AI/ML tools for integrating metabolomics, transcriptomics, and genomics datasets across development and disease

Requirements

• Ph.D. and/or M.D. degree
• Strong background in hematology/oncology, metabolism research, biochemistry, molecular biology, and/or a related field

Qualifications

The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity.

Skills

• Previous experience in metabolomics, computational biology, and/or hematology‑oncology is strongly preferred