Postdoctoral Fellow - Structural Biology and Drug Discovery

Job Summary

The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated postdoctoral fellow to join a multidisciplinary drug discovery program focused on a metabolic enzyme that plays a central role in cholesterol homeostasis and bile acid synthesis.

Responsibilities

• Lead efforts in recombinant protein expression and purification, and structure determination using X-ray crystallography to enable structure-guided ligand design.
• Collaborate at the interface of structural biology, chemical biology, and translational therapeutics, contributing to the development of first-in-class modulators targeting a clinically relevant metabolic pathway.

Requirements

• Ph.D. in life sciences, biomedical sciences, or a related discipline is required.
• Prior experience in protein biochemistry and X-ray crystallography is essential.
• Experience in quantitative biophysical characterization of small-molecule binding studies such as SPR, ITC, and DSF and/or an interest in mechanism-driven drug discovery and fragment-based approaches is highly desirable.
• Proven track record of successful research projects and publications.
• Excellent analytical and problem-solving skills.
• Effective communication and collaboration abilities.

Qualifications

• Ph.D. in life sciences, biomedical sciences, or a related discipline is required.

Skills

• Proven track record of successful research projects and publications.
• Excellent analytical and problem-solving skills.
• Effective communication and collaboration abilities.

Benefits

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

Pay

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

Schedule

City of Hope employees work hours are flexible to accommodate their needs and the demands of their roles.

Benefits

City of Hope offers comprehensive benefits including health insurance, retirement plans, and paid time off.

Contact Information

To learn more about our Comprehensive Benefits, please CLICK HERE.