Postdoctoral Fellow - Cancer Immunology and Immunotherapy

About the role

The laboratory of Dr. Shoubao Ma at the City of Hope National Medical Center is seeking a highly motivated postdoctoral fellow to join our research team. The Ma Lab is dedicated to advancing the understanding and application of cancer immunology and immunotherapy.

Responsibilities

• Molecular and cellular regulation of natural killer (NK) cells.
• Study mechanisms that control NK cell development, differentiation, activation, and effector function.
• Understand how NK cells recognize and eliminate malignant cells.
• Mechanisms of tumor immune evasion.
• Identify genes and pathways that enable tumor cells to evade immune attack.
• Develop and optimize NK cell-based immunotherapies, including chimeric antigen receptor (CAR)-NK cells.
• Explore transformative approaches to improve the persistence, potency, trafficking, and safety of engineered NK cells.
• Contribute to the development of in vivo CAR therapies that directly reprogram immune cells within the patient.

Requirements

• Ph.D. degree in life or biomedical sciences, or a related discipline.
• Experience in NK cell development and function.
• Knowledge of tumor immunology and immunotherapy.
• Experience with ex vivo and/or in vivo CAR NK or CAR T cell engineering.
• Experience with CRISPR screening and CRISPR-based gene editing.
• At least one first-author publication in a high-impact journal.
• Excellent communication skills and fluency in English.
• Strong team orientation and interpersonal skills.

Qualifications

• Ph.D. degree in life or biomedical sciences, or a related discipline.
• Experience in NK cell development and function.
• Knowledge of tumor immunology and immunotherapy.
• Experience with ex vivo and/or in vivo CAR NK or CAR T cell engineering.
• Experience with CRISPR screening and CRISPR-based gene editing.
• At least one first-author publication in a high-impact journal.
• Excellent communication skills and fluency in English.
• Strong team orientation and interpersonal skills.

Skills

• Experience in molecular and cellular regulation of NK cells.
• Knowledge of tumor immune evasion mechanisms.
• Ability to develop and optimize NK cell-based immunotherapies.
• Experience with CRISPR-based functional genomics approaches.
• Strong communication and teamwork skills.

Benefits

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

Pay

City of Hope employees' pay is determined based on their work experience, qualifications, and work location.

Schedule

The position offers a competitive schedule designed to support your professional and personal growth.

Additional Information

To learn more about our Comprehensive Benefits, please CLICK HERE.

Equal Opportunity Employer

City of Hope is an equal opportunity employer.