Post Doctoral Scientist - Molecular Pharmacology

About the role

The role is located in Indianapolis, Indiana and is a fixed-term position up to 2 years with a possible 2-year extension. This is an onsite position.

Responsibilities

• Conduct innovative molecular pharmacology studies to characterize the mechanisms of action of GPCR ligands across multiple receptor systems of therapeutic relevance.
• Work with and be mentored by industry-leading molecular pharmacologists, structural biologists, computational scientists, and medicinal chemists.
• Present findings at internal and external scientific meetings and publish extensively in high-quality peer-reviewed journals.

Requirements

• PhD in pharmacology, biochemistry, biophysics, molecular biology, or a closely related life science discipline with all completed requirements by October 2026.
• Basic Qualifications: Authorized to work in the United States on a full-time basis.

Qualifications

• Training or background in membrane receptor biology, receptor pharmacology, signal transduction, or quantitative pharmacology would be advantageous.
• Self-directed and highly motivated, with a commitment to pursuing both technical excellence and publication goals.
• Excellent communicator (oral and written) with a strong or developing publication record.
• Proficient in data analysis, graphing, and scientific reporting (e.g., GraphPad Prism, Python, Excel, PyMOL, MOE).
• Experience with ligand binding techniques (competition, saturation, kinetic assays) in live cell or membrane formats.
• Experience with cell-based GPCR signaling assays, including cAMP, IP1, β-arrestin recruitment, intracellular calcium measurement, or phosphoprotein measurement.
• Familiarity with quantitative pharmacological modelling or kinetic simulation approaches.
• Understanding or practical experience of modern structural and computational biology approaches.
• Interest in the mechanistic and theoretical foundations of receptor pharmacology.

Skills

• Training or background in membrane receptor biology, receptor pharmacology, signal transduction, or quantitative pharmacology would be advantageous.
• Self-directed and highly motivated, with a commitment to pursuing both technical excellence and publication goals.
• Excellent communicator (oral and written) with a strong or developing publication record.
• Proficient in data analysis, graphing, and scientific reporting (e.g., GraphPad Prism, Python, Excel, PyMOL, MOE).
• Experience with ligand binding techniques (competition, saturation, kinetic assays) in live cell or membrane formats.
• Experience with cell-based GPCR signaling assays, including cAMP, IP1, β-arrestin recruitment, intracellular calcium measurement, or phosphoprotein measurement.
• Familiarity with quantitative pharmacological modelling or kinetic simulation approaches.
• Understanding or practical experience of modern structural and computational biology approaches.
• Interest in the mechanistic and theoretical foundations of receptor pharmacology.