Pharmacology Principal Research Associate

About the role

The Pharmacology Principal Research Associate is responsible for delivering high-quality, independent research to evaluate the effects of compounds on ex vivo and/or in vivo disease biology. This individual demonstrates advanced technical proficiency, strong attention to detail, and the ability to troubleshoot and adapt methodological approaches.

Responsibilities

• Design, execute, and interpret in vivo experiments with a high degree of independence and reliability
• Lead and support flow cytometry analysis and cell sorting workflows for ex vivo samples collected from rodent and large animal studies
• Perform sample/cell preparation, staining, acquisition, panel optimization, gating analysis, and sorting with strong technical rigor
• Apply sound judgment to prioritize studies based on project impact
• Conduct basic in vivo procedures, including:
• Animal handling
• Dosing through multiple routes of administration (ROAs)
• Perfusion
• Blood and other fluid sample collection
• Tissue dissection and processing
• Perform basic analytical assays, including ELISA analysis of serum and urine samples
• Perform basic statistical analyses of experimental data, as appropriate
• Independently troubleshoot experimental challenges and refine protocols as needed
• Contribute to publication and patent submission processes
• Prepare clear, well-structured protocols, study plans, and reports
• Stay current with relevant scientific literature and emerging trends
• Present findings effectively at internal group, department, or project meetings
• Perform additional duties as assigned

Knowledge and Skills

• Strong technical expertise in flow cytometry analysis and cell sorting, including work with ex vivo samples from rodent and large animal tissues
• Demonstrated proficiency in designing and interpreting experiments to assess compound effects in ex vivo and/or in vivo disease models
• Hands-on experience with basic in vivo pharmacology techniques, including animal handling, dosing via multiple ROAs, perfusion, fluid collection, and tissue dissection/processing
• Experience with basic analytical methods, including ELISA assays for serum and urine samples
• Solid understanding of core biological and immunological principles
• Ability to independently design, execute, and interpret follow-up experiments
• Strong analytical skills, including interpretation of complex datasets and refinement of experimental protocols
• Proven reliability, particularly in high-impact or sensitive studies
• Effective written and verbal communication skills within area(s) of expertise
• Developing knowledge of related scientific disciplines; background in muscular dystrophy and/or cystic kidney disease is a plus

Education and Experience

• Bachelor’s degree in a biological science required
• Typically requires: Bachelor’s degree with 5+ years of experience, or Master’s degree with 2+ years of experience