Oligonucleotide Method Development & Validation

Job Summary

The Oligonucleotide Scientist is responsible for developing, optimizing, validating, and executing analytical methods to support oligonucleotide API, drug substance, and drug product testing. The role supports pharmaceutical clients throughout various stages of the drug pipeline but does not support or include synthesis/manufacturing of oligonucleotides. The role focuses primarily on HPLC/UHPLC and mass spectrometry (e.g., LC‑MS, LC‑MS/MS) for identity, purity/impurity profiling, quantitation, and stability-indicating assessments.

Qualifications

• Excellent communication (oral and written) and attention to detail.
• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude.
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
• Minimum Qualifications: At least a BS or MS degree in Analytical Chemistry or related scientific discipline, BS and 4+ years, MS and 2+ years, or PhD and 1+ year of relevant industry experience.
• Experience performing analytical testing with oligonucleotides in a GMP-regulated environment.
• Strong theoretical and practical knowledge of chromatography (HPLC, UHPLC, IEX, SEC) and mass spectrometry, including method development, validation, and routine testing.
• Regulatory Knowledge: Familiarity with ICH guidelines and GxP regulatory standards.
• Background should be primarily in analytical testing or analytical method development; candidates with primarily synthesis or process chemistry experience without analytical/QC responsibilities will not be considered.
• Authorization to work in the U.S. indefinitely without restriction or sponsorship.

Additional Information

• Working schedule will be Full-Time, First Shift, Mon-Fri, 8am-4pm.
• Candidates currently living within a commutable distance of Lancaster, PA are encouraged to apply.
• 25% travel may be required.
• This position is NOT remote.

What We Offer

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options.
• Lifetime Life and disability insurance.
• 401(k) with company match.
• Paid vacation and holidays.