National Account Director (Optum & Emisar)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial stage biopharmaceutical company that develops medicines treating intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a natural cellular process that inhibits the expression of specific genes, thereby affecting protein production. Arrowhead’s RNAi-based therapeutics leverage this pathway to address diseases with a genetic basis, typically characterized by the overproduction of disease-related proteins. The depth and versatility of our RNAi technologies enable us to potentially address conditions across virtually any therapeutic area, including targets not addressable by small molecules and biologics. Arrowhead is leading the field in bringing RNAi therapies outside of the liver, with a clinical pipeline targeting liver and lung diseases and a promising preclinical pipeline. Corporate headquarters are in Pasadena, CA, with research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

The National Account Director (NAD) will play a critical role in enabling patient access to Arrowhead’s first commercial asset—Redemplo (plozasiran, siRNA targeting APOC3)—as well as an expanding pipeline of innovative therapies across multiple therapeutic areas. Redemplo has demonstrated compelling clinical data and received approval in November 2025 for the treatment of Familial Chylomicronemia Syndrome (FCS), with late-stage development continuing for Severe Hypertriglyceridemia (SHTG). The NAD will develop, execute, and manage strategic relationships with key stakeholders across the Emisar (GPO) and Optum (PBM) books of business, along with their affiliated Commercial and Medicare plan stakeholders, to secure formulary access. This field-based role requires periodic travel to Arrowhead’s corporate headquarters in Pasadena, CA.

Responsibilities

• Strengthen relationships with Emisar (GPO) and Optum (PBM) books of business across payer segments.
• Communicate product clinical and economic value to payers and key decision-makers.
• Create and maintain comprehensive account plans supporting launch and post-launch strategies.
• Lead contract negotiations, evaluate performance metrics, and ensure organizational alignment.
• Help develop the organizational structure and capabilities required to support effective payer engagement across the expanding U.S. Arrowhead portfolio.
• Monitor sales implications for each payer negotiation and take action to establish optimal access.
• Collaborate with cross-functional teams within Market Access, Sales, Medical Affairs, Commercial Analytics, Finance, and Compliance to address access challenges.
• Provide market intelligence updates on payer trends, coverage determinations, and healthcare policy changes.
• Present payer policy insights at internal business reviews, national conferences, and sales meetings to align strategic priorities.
• Ensure full compliance with U.S. healthcare regulations, legal standards, and corporate policies.
• Align with payer-affiliated Integrated Delivery Networks (IDNs) within the assigned geography to support a coordinated account strategy.

Requirements

• Bachelor’s degree.
• 12+ years of pharmaceutical/biotech experience with a strong background in field-based market access, payer engagement, or managed markets.
• 5+ years of previous national account payer experience with established, deep-rooted relationships across the Optum enterprise, including Emisar GPO.
• Strong understanding of commercial and Medicare Part D managed care processes.
• Previous experience launching rare disease/cardiometabolic medicines highly desired.
• Experience managing national and local contracting initiatives in managed care organizations.
• Demonstrated ability to drive results and influence cross-functionally without direct authority to support an expanding portfolio of innovative therapies.
• Excellent communication, negotiation, and presentation skills.
• Ability to translate complex scientific and economic data into payer-relevant insights.
• Self-motivated, collaborative, and able to operate with strategic independence.
• Willingness to travel up to 50%.

Preferred Qualifications

• Advanced degree (MBA, MPH, PharmD).

Pay

California pay range: $230,000 USD - $250,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.