HEOR Ops & Analytics Associate Director

About the role

Vertex is seeking a talented and motivated individual to join a highly innovative company focused on transforming the lives of people with serious diseases, their families, and society. This Associate Director role is within HEOR’s Analytics Center of Excellence (CoE), a specialized team providing strategic and technical support to HEOR, Market Access & Pricing, and the broader commercial organization.

The Associate Director will primarily support HEOR disease/asset teams in real-world observational and claims data research activities, leveraging Vertex’s in-licensed real-world evidence (RWE) data assets. This includes planning and conducting analyses to address key questions related to disease prevalence, burden and progression, healthcare resource utilization and costs, and treatment patterns in real-world patient populations. The role also involves providing methodological expertise in research design, including development of study protocols, analysis plans, and table shells, and collaborating with statistical programmers to execute data queries and analyses.

The Associate Director may contribute to global product value strategy, post-hoc clinical trial analyses, and evidence generation studies. The role offers flexibility to be in-person, hybrid, or remote.

Responsibilities

• Conduct feasibility assessments to inform design and execution of research projects.
• Perform health economic and outcomes research to characterize disease burden, healthcare resource utilization, comorbidities, and treatment patterns in real-world populations.
• Generate actionable insights to address key business questions from internal and external stakeholders.
• Lead the development of study protocols, statistical analysis plans, and table shells.
• Support statistical programmers through the execution of data queries and analyses.
• Generate analytic reports, tables, and visualizations to communicate research findings effectively to internal stakeholders.
• Collaborate with cross-functional colleagues to improve efficiency of the current analytics operating model.
• Contribute to the development, enhancement, and maintenance of internal analytic tools (e.g., programming libraries, reusable macros, table templates) to support data quality and consistency.
• Support HEOR disease/asset leads in assessing research gaps and evidence generation objectives addressable through observational research.

Requirements

• Advanced degree in health economics or a related quantitative discipline (e.g., mathematics, statistics, economics, epidemiology).
• Typically requires 8 years of relevant experience in health economics and outcomes research, or an equivalent combination of education and experience (e.g., Doctorate degree and 4 years of experience, Master’s degree and 6 years of experience).
• Strong knowledge of observational research methods and their application to studies assessing disease burden, healthcare resource utilization, treatment patterns, comorbidities, and health outcomes in real-world patient populations.
• Demonstrated experience applying claims-based analytic methods in epidemiologic research, including disease prevalence estimation and evaluation of patient populations using real-world data sources.
• Hands-on experience analyzing large patient-level healthcare datasets, including open and closed claims, EHR/EMR data, and hospital chargemaster data (e.g., MarketScan, PharMetrics Plus, eLAAD+, Premier).
• Working knowledge of national healthcare coding systems, including diagnostic, procedure, and drug coding, as well as relevant healthcare system structures.
• Advanced proficiency in SAS programming and Excel.
• Excellent written and oral communication skills, including the ability to clearly convey complex analytic findings to both technical and non-technical audiences.
• Ability to plan, organize, and manage multiple projects simultaneously across different therapeutic areas.
• Ability to navigate and succeed in a fast-paced, dynamic, and collaborative team-based environment.

Pay

The pay range for this role is $172,000 - $258,000. This range reflects the base salary and does not include annual bonus, equity awards, or overtime pay (where applicable). Actual base salary will be determined based on skills, competencies, experience, and other job-related factors permitted by law.

Benefits

• Inclusive market-leading medical, dental, and vision benefits.
• Generous paid time off, including a week-long company shutdown in the Summer and Winter.
• Educational assistance programs, including student loan repayment.
• Generous commuting subsidy.
• Matching charitable donations.
• 401(k) retirement plan.

Schedule

This role is remote-eligible with flexibility to be designated as:

• Remote: Work remotely five days per week with occasional office visits.
• Hybrid: Work remotely up to two days per week.
• On-Site: Work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.