Head of Cell Line Development

About the role

At Alloy Therapeutics, as Head of Cell Line Development, you will lead technology evaluation, development, and strategy for stable cell line technologies. This is a senior leadership role responsible for shaping the scientific and technical direction of our cell line development capabilities, ensuring we remain at the forefront of innovation in stable transfection, clone selection, and cell line engineering.

Responsibilities

• Drive: Scientific direction and execution of cell line technology development projects
• Innovate: Ensure the application of cutting-edge technologies and methodologies in cell line engineering
• Collaborate: Integrate cell line development product offerings and engage with external collaborators in preparation of manufacturing of biologics
• Deliver: Efficient execution of partner projects balancing quality, timelines, and costs, while ensuring successful completion of cell line production that meet our partners’ objectives
• Lead: Marshall, inspire, and mentor a cross-functional team of scientists. Lead by example by going the extra mile to ensure we are successful delivering on projects
• Communicate: Communicate effectively with key stakeholders externally and internally, fostering productive interactions both upward and downward, and across teams at different sites

Requirements

• Ph.D. in Cell Biology, Molecular Biology, Biochemical Engineering, or a related field
• 10+ years of hands-on experience in cell line development within a CDMO or pharmaceutical/biotech company setting
• Deep familiarity with current and emerging technologies for stable transfection and cell line generation (e.g., electroporation, lipofection, viral-mediated delivery, targeted integration systems, novel selection markers, high-throughput clone screening platforms)
• Strong understanding of clone selection, cell banking, stability testing, and characterization requirements (including regulatory expectations such as ICH Q5D)
• Excellent communication skills, with experience presenting to internal leadership, clients, and/or regulatory bodies

Qualifications

• Prior experience evaluating or implementing novel cell line development platforms (e.g., targeted integration systems, next-generation expression vectors, single-cell dispensing/imaging technologies)
• Experience with GMP-regulated environments and technology transfer to manufacturing
• Track record of publications, patents, or conference presentations in cell line development
• Experience in a client-facing CDMO environment