Global Program Operations Head (GPOH)

Overview

Tango Therapeutics is a biotechnology company focused on discovering novel drug targets and delivering precision medicine for cancer. Located at 201 Brookline Avenue in Boston, MA, Tango uses synthetic lethality to develop therapies targeting critical cancer-related genes.

Role

Lead the strategic and operational execution of a portfolio of clinical trials within a designated disease area. Ensure alignment with corporate goals and regulatory standards. Represent Global Clinical Operations in Global Program Teams (GPTs) and sub-teams, contributing to program-level strategy and operational planning. Collaborate with Medical and Regulatory Directors to ensure clinical strategies are scientifically sound, meet regulatory requirements, and are operationally feasible. Partner with Operational Excellence & Clinical Compliance to align on risk assessment, trial- and site management metrics, KPIs, and KRIs. Define and implement outsourcing strategies in partnership with the VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting. Monitor trial progress and key deliverables, guiding Clinical Trial Teams (CTTs) in execution planning, issue resolution, and risk mitigation. Manage program and trial budgets, ensuring accurate forecasting, cost control, and financial accountability. Track CRO/vendor performance using metrics, KPIs, KRIs and participate in governance meetings to address escalated issues and drive continuous improvement. Provide regular updates on trial progress to internal governance bodies, including GPT and Executive Leadership Team. Support inspection readiness activities and represent the organization during Health Authority inspections. Provide leadership, coaching, and performance management to Clinical Trial Leaders (CTLs), Clinical Contract Managers (CTMs), Clinical Trial Specialists (CTSs), and Site Management Leader (SMLs). Set clear objectives, deliver ongoing feedback, and develop tailored development plans to support team growth and capability building. Oversee hiring, onboarding, and training of new team members, fostering a culture of operational excellence and continuous learning.

Requirements

• 12+ years of trial management experience with 7+ years in leadership position
• Bachelor’s degree in Life Sciences, Pharmacy or related field (required)
• Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred)
• Significant experience working in global clinical development organization
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections
• Significant experience in outsourcing and oversight
• Expert knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Expert knowledge in financial planning, tracking, and reporting
• Expert knowledge in risk assessment and management on program and trial-level
• Strong decision-making and sound judgment
• Strong leadership and interpersonal skills
• High credibility with senior leadership
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs
• Willingness to travel, as required (typically 10–20%)

Benefits

We are an equal opportunity employer and value diversity at our company.

Pay

$225,600—$338,400 USD