Global Development Global Clinical Program Lead, Hematology Oncology

About the role

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company focused on the discovery, development, and commercialization of prescription medicines for serious diseases. Within Hematology R&D, we are committed to advancing science to deliver life-changing medicines to patients in need. This unit oversees the value chain from discovery through late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

The Hematology Research and Early Development (R&D) team is accountable for all drug development activities in hematology research, from first-in-human studies to late-stage trials leading to drug approval (Phase 1, 2, and 3 trials). The team delivers compelling preclinical, clinical, and translational data packages to support investment in late-stage clinical development and regulatory approval.

We seek a highly qualified Global Clinical Program Lead (GCPL) to lead the clinical development and execution of the product strategy for multiple projects. This individual will be accountable for the strategic clinical development plan and execution of compounds, reporting to the Global Clinical Head (GCH) of the disease indication. The role involves articulating project goals, strategy, and underlying science to internal and external audiences with clarity and credibility.

Responsibilities

• Lead clinical development teams responsible for novel Hematology Oncology therapies from preclinical candidate selection through proof of concept, leading to Phase 3 investment decisions.
• Accountable for the clinical strategy and execution of a portfolio of preclinical and clinical-stage therapies, ensuring delivery according to quality, time, budgets, and resources.
• Build strategic and coordinated clinical development plans aligned with business objectives and differentiated from competitor products.
• Accountable for executing the integrated product plan to agreed scope, timelines, and budgets.
• Lead and communicate the clinical development strategy at governance meetings, aligning with internal management and external collaborators.
• Responsible for all clinical aspects of project strategy, including translational, clinical development, patient selection, regulatory, pediatric, and Asian development strategy.
• Develop the Target Product Profile, ensuring alignment with disease area strategy and late-stage development.
• Co-lead the Clinical Program Team (CPT) to effectively manage risk, make decisions, and handle conflict and change.
• Maintain high CPT effectiveness through collaboration, influence, and coaching of cross-functional team members.
• Ensure robust processes, plans, and data to enable Governance Bodies to make investment decisions and prioritize projects across the portfolio.
• Lead all regulatory submissions for assigned projects.

Requirements

• M.D. is required.
• A minimum of 7 years of relevant experience in drug development, including early and late-phase drug development and regulatory knowledge.
• Strong knowledge and understanding of the Hematology Oncology therapeutic area, with experience in diverse biological mechanisms.
• Broad understanding of the evolving clinical landscape in hematology/oncology.
• Proven experience mentoring and motivating teams in a highly matrixed environment.
• Demonstrated organizational and project management skills.
• Proven success in influencing colleagues and senior leaders across departments.
• High integrity and ability to lead internal and external cross-functional collaborations.

Benefits

• Annual base pay range: $288,059 – $432,088 (offer may vary based on market location, job-related knowledge, skills, and experience).
• Short-term incentive bonus opportunity.
• Eligibility to participate in equity-based long-term incentive program (salaried roles).
• Retirement contribution (hourly roles) or qualified retirement program [401(k) plan] (salaried roles).
• Paid vacation, holidays, and leaves.
• Health benefits, including medical, prescription drug, dental, and vision coverage.

Schedule

Hybrid working: In the office a minimum of 3 days per week.

Location: Gaithersburg, United States.