Global Clinical Program Lead, Hematology R&D

Hybrid working: Minimum of 3 days per week in the office. Locations: Gaithersburg, Maryland; Boston, Massachusetts; South San Francisco, California or Manhattan, New York.

About the Group

The Hematology Research and Early Development (R&D) team is accountable for all drug development activities in hematology research from first-in-human studies through late-stage trials leading to drug approval by regulatory agencies (Phase 1, 2, and 3 trials). The team delivers compelling preclinical, clinical, and translational data packages to support investment in late-stage clinical development and drug approval.

About the Role

We are seeking a highly qualified Global Clinical Program Lead (GCPL) to lead the clinical development and execution of the product strategy for multiple projects. This individual will be accountable for the strategic clinical development plan and clinical execution of compounds, reporting to the Global Clinical Head (GCH) of the disease indication. The role involves collaborating with project leaders, scientific and clinical leaders, and external experts to coordinate integrated project plans across functional boundaries. The candidate will ensure diverse perspectives are heard and foster a strongly empowered and motivated team while demonstrating leadership within the oncology community, both internally and externally.

Responsibilities

• Leads clinical development teams responsible for novel hematology/oncology therapies from preclinical candidate selection through proof of concept, leading to Phase 3 investment decisions.
• Leads all regulatory submissions.
• Accountable for the clinical strategy and execution of a portfolio of preclinical and clinical-stage therapies.
• Ensures delivery of projects according to quality, time, budget, and resource constraints.
• Builds strategic and coordinated clinical development plans aligned with business objectives and differentiated from competitor products.
• Accountable for executing the integrated product plan to agreed scope, timelines, and budgets.
• Leads and communicates the clinical development strategy at governance meetings, aligning with internal management and external collaborators.
• Leads clinical aspects of projects from preclinical Lead Optimization Investment Decision to clinical Proof of Concept (PoC), including:
  • Clinical strategy (translational, clinical development, patient selection, regulatory, pediatric, and Asian development).
  • Development of the Target Product Profile, ensuring alignment with disease area strategy and late-stage development.
• Co-leads the Clinical Program Team (CPT) to effectively manage risk, decision-making, conflict, and change.
• Ensures high CPT effectiveness through collaboration, influence, coaching, and mentoring of cross-functional team members.
• Ensures robust processes, plans, and data to enable Governance Bodies to make investment decisions and prioritize projects across the portfolio.
• Primary clinical focus on CLL and related lymphoid malignancies in both early and late-stage studies, with potential expansion to other areas.

Requirements

• M.D. is required.
• A minimum of 7 years of relevant experience in drug development, including early and late-phase clinical trials and regulatory knowledge.
• Hematology/oncology clinical drug development experience with demonstrated leadership.
• Ability to critically navigate the science underlying these programs.
• Strong communication skills to articulate project-specific and overall oncology strategies across diverse audiences.
• In-depth knowledge of the Hematology Oncology therapeutic area, including experience with diverse biological mechanisms.
• Broad understanding of the evolving clinical landscape in hematology/oncology.
• Proven experience in mentoring and motivating teams in a highly matrixed environment.
• Demonstrated ability to lead internal and external cross-functional collaborations.
• Strong organizational and project management skills.
• Proven success in influencing colleagues and senior leaders across departments.
• High integrity and ethical standards.

Pay

The annual base pay for this position ranges from $288,059 to $432,089. Base pay may vary depending on market location, job-related knowledge, skills, and experience. Eligible positions also offer a short-term incentive bonus, equity-based long-term incentives (for salaried roles), retirement contributions (for hourly roles), and commission eligibility (for sales roles).

Benefits

• Qualified retirement program (401(k) plan).
• Paid vacation and holidays.
• Paid leaves.
• Health benefits, including medical, prescription drug, dental, and vision coverage.