FA27-037: Post-Doctoral Fellow (2 Openings)

Type Full-Time (2 positions) Category Chemistry Appointment Status Postdoctoral Fellow (Non-Tenure Track) Start date As soon as possible Department Pharmaceutical Sciences, Southern Illinois University Edwardsville Location Edwardsville, IL., USA (St. Louis Metro Region) Position Summary The Department of Pharmaceutical Sciences in the School of Pharmacy, Southern Illinois University Edwardsville is recruiting 2 highly motivated postdoctoral researchers. These positions focus on designing and synthesizing small molecules to support the discovery and development of therapeutics for Alzheimer’s disease. We seek individuals with demonstrated experience in chemical synthesis, purification, and characterization of starting materials using standard techniques (Nuclear Magnetic Resonance, high-pressure liquid chromatography, mass spectrometry, etc.). Successful applicants will use a deep understanding of synthetic organic chemistry to synthesize and purify small molecules targeted to the brain. Candidates will also design or modify laboratory procedures and protocols, develop experimental designs, optimize lead molecules based on structure-activity relationship (SAR) studies, gather and analyze data, maintain notebook, and effectively report results at weekly meetings. Individuals will receive regular guidance to ensure progress is made toward their goals. The initial appointment for this position will be for 12 months, subject to performance reviews. Extensions will be available based on performance. Research Environment and Facilities The research program is supported by well-equipped medicinal chemistry, analytical, and molecular pharmacology facilities, providing the infrastructure required for small-molecule discovery, characterization, and biological evaluation. Synthetic and medicinal chemistry: Automated flash chromatography systems, preparative HPLC, microwave synthesizer, rotary evaporators, and lyophilization.Compound characterization and analysis: 400 MHz multi-nuclei FT-NMR, LCMS, FT-IR, UV-Vis spectroscopy, polarimetry, and gel imaging systemsBiochemical and pharmacological evaluation: Plate readers, luminometry, scintillation and gamma counting, flow cytometry, and surface plasmon resonance.Cellular and molecular biology: Inverted fluorescence and confocal microscopy, cryostat facilities, and RT-qPCR. Qualifications Application Qualifications Motivated applicants with a Ph.D. and research experience in medicinal chemistry, organic synthesis, or related areas are particularly encouraged to apply. Instructions Application submission: INTERFOLIO Interested candidates should submit a cover letter supporting the application and associated career objectives, CV, and contact information for three references alongside their electronic application in Interfolio. Applications will be reviewed upon receipt. Contact for Questions For additional information or questions about the positions, research program, or application requirements, please contact Dr. Bhargav Patel (bhapate@siue.edu). Applicants will be subject to a background check prior to an offer of employment. Employment is contingent upon satisfying all legal requirements as set forth by the U.S. Citizenship and Immigration Services in regard to employability in the United States. SIUE makes no representation, warranty, or agreement that third parties, including government agencies, will approve submitted documents, applications, or petitions for an H-1B visa or Optional Practical Training. SIUE is a state university - benefits under state sponsored plans may not be available to holders of F1 or J1 visas. The State of Illinois requires that immigrant employees achieve H-1 status before they become eligible for certain benefits. EEO Statement Southern Illinois University Edwardsville is an equal opportunity employer and thus prohibits discrimination against employees, applicants for employment and students on the basis of age, color, disability, marital status, national origin, race, religion, sex, sexual orientation, or veteran's status.