Executive Director, US Region Operations

About the role

Revolution Medicines is a global, commercial-stage oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

Responsibilities

• Partner closely with the U.S. General Manager and cross-functional U.S. Region Leadership Team (USxLT) to drive impact for patients and the business.
• Develop and implement key business processes, lead operations, and shape how the organization scales.
• Ensure connectivity and strong communication across and beyond the function.
• Partner with U.S. Region, Global Commercialization, Finance, Legal, and other cross-functional stakeholders to drive alignment, execution, and organizational effectiveness across a diverse portfolio of global commercialization priorities.
• Establish and evolve scalable frameworks, planning processes, governance structures, and organizational capabilities that strengthen execution and support future growth.
• Guide and execute region strategies, plans, and deliverables in collaboration with the U.S. General Manager and Heads of U.S. Marketing/Field, Market Access, Medical Affairs, Analytics & Insights, and Key Partners (e.g., HR, Finance, Legal/Compliance, IT/Business Systems, Corporate Relations).
• Establish and plan financial and strategic Key Operational review processes (Brand & Launch Planning, Business Reviews, Budgets, Projections) for U.S. Region and coordinate appropriate reviews with USxLT and beyond.
• Lead coordination of key management presentations: content and FAQ coordination for key meetings including BoD and earnings presentations, launch readiness, performance, policy/access reviews, and other key reviews.
• Define U.S. Region organizational goals and strategic priorities (short and long term and as part of company goals); set, track, review, and communicate progress regularly.
• Lead setup and planning for USxLT meetings and other internal commercialization decision-making meetings in close collaboration with relevant members.
• Support the U.S. General Manager and Region to develop and implement a communication strategy that drives a connected and motivated team.
• Ensure operational processes and procedures are in place to drive an outcome-driven and effective USxLT and Region organization (leading governance and meeting setup, agendas, minutes, etc.).
• Partner with Global Commercial Operations on shared deliverables and to drive alignment and identification of synergies broadly.
• Optimize the effectiveness of interfaces across key functions to ensure collaboration and understanding of key initiatives and priorities.
• Build and scale commercialization effectiveness capabilities, including project management, operations, governance, planning, tools, dashboards, and performance management processes.
• Provide direct operational leadership across the region, ensuring efficient planning cycles, operational discipline, and execution consistency.
• Champion effective operational and change management strategies with an enterprise mindset and lead change adoption efforts related to tools, processes, and ways of working to ensure sustainable implementation with consideration of future scalability and organizational growth.
• Develop, grow, and lead a high-performing operations and administration team, creating scalable capabilities and ways of working that support the future needs of the organization.
• Provide executive leadership and oversight in collaboration with Legal, Compliance, Medical, Finance, and other stakeholders to establish and maintain appropriate commercial governance, SOPs, and controls that enable effective, compliant commercialization in accordance with applicable laws, regulations, industry standards, and company policies.
• Champion “One RevMed” Culture: take ownership for fostering and maintaining a unified, inclusive, and high-performing culture across all segments of the organization—local operating companies, global commercialization, R&D, G&A, etc.
• Develop and implement initiatives that ensure every employee, regardless of location or function, experiences a consistent and positive “One RevMed” environment.
• Collaborate with leadership and HR to embed core values, drive engagement, and reinforce cultural alignment throughout RVMD.

Requirements

• Bachelor’s degree with 15+ years of relevant experience in biotech, pharmaceutical, or healthcare industry, including significant experience leading complex commercial or commercialization initiatives.
• Experience supporting commercialization organizations, including involvement in launch readiness, brand planning, operational planning, and capability buildout.
• Demonstrated Executive Director-level capability, including defining operating models, building scalable organizational capabilities, and driving cross-functional alignment in evolving organizations.
• Strong operational leadership skills, including process design, governance, performance management, change management expertise, and cross-functional coordination.
• Proven success partnering with senior commercial, medical, sales, analytics, and access leaders to enable organizational effectiveness.
• Experience building and scaling high-performing teams and organizational capabilities.
• Track record of thriving in ambiguous, fast-moving environments with a hands-on, builder mindset.
• Exceptional communication and interpersonal skills, with the ability to translate complexity into clear and actionable frameworks.
• Strong systems thinking, judgment, and a continuous improvement mindset.

Preferred Skills

• Advanced degree (MBA/MS/PhD).
• Oncology/specialty pharma commercialization experience.
• Experience building and leading commercialization operations, PMO, organizational effectiveness, or business operations functions.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $252,000 – $315,000 USD. The range displayed is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Base pay is determined by role, level, location, job-related skills, experience, market dynamics, and relevant education or training.