DoW Multiple Sclerosis Clinical Trial Award

Funding Opportunity Number: HT942526MSRPCTA

About the opportunity

The fiscal year 2026 (FY26) Multiple Sclerosis Research Program (MSRP) Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of multiple sclerosis.

All applications must address at least one of the FY26 MSRP CTA focus areas. Clinical trials may evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies.

Distinctive features

The FY26 CTA offers two funding levels:

• Funding Level 1 (CTA-FL1): Supports small-scale, proof-of-principle clinical trials (e.g., pilot, first-in-human, phase 0) to demonstrate feasibility or inform the design of more advanced trials, or other clinical trials appropriate for this funding level. Preliminary data relevant to the proposed clinical trial are required.
• Funding Level 2 (CTA-FL2): Supports larger-scale clinical trials at phase 1 or phase 2 that seek to show preliminary evidence of safety or efficacy (i.e., benefit of clinical or paraclinical outcomes) in relevant patient populations. Clear description and justification should be provided, which could include, but is not limited to, the intervention type, trial duration, sample size, outcome measures, assessment tools, and frequency of assessment. Preliminary data relevant to the proposed clinical trial in MS populations are required.

For the purposes of this funding opportunity, Regulatory Agency refers to the U.S. Food and Drug Administration (FDA) or any relevant international regulatory agency unless otherwise noted.

Eligibility

Eligible Applicants: Unrestricted (i.e., open to any type of entity), subject to any clarification in the "Additional Information on Eligibility" section.

Funding details

• Estimated Total Program Funding: $4,000,000
• Expected Number of Awards: 3
• Cost Sharing or Matching Requirement: No
• Assistance Listings: 12.420 -- Military Medical Research and Development

Key dates

• Posted Date: May 05, 2026
• Last Updated Date: May 05, 2026
• Current Closing Date for Applications: August 13, 2026
• Archive Date: September 12, 2026

Contact information

If you have difficulty accessing the full announcement electronically, please contact:

• eBRAP Help Desk: Phone: 301-682-5507, Email: help@eBRAP.org
• CDMRP Help Desk