DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

Funding Opportunity Number: HT942526ALSRPPCTA

About the Opportunity

The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to significantly impact the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.

Focus Areas

Applications must address one of the following focus areas:

• Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.
• Clinical Care: Improving aspects of clinical care and symptom management for ALS.

Distinctive Features

• Funding must support a clinical trial, beginning no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.
• Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.
• All pre-applications and applications must incorporate community collaboration to optimize research impact.
• Applications must include a detailed Regulatory Strategy plan outlining the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study.
• Applications must provide a separate Transition Plan describing how the outcomes of the study will advance to the next phase of development beyond the funded work.

Eligibility

Eligible applicants: Unrestricted (open to any type of entity).

Funding Details

• Estimated Total Program Funding: $5,600,000
• Expected Number of Awards: 2
• Assistance Listing: 12.420 -- Military Medical Research and Development
• Cost Sharing or Matching Requirement: No

Key Dates

• Posted Date: May 04, 2026
• Last Updated Date: June 17, 2026
• Closing Date for Applications: September 30, 2026
• Archive Date: October 30, 2026

Contact Information

For assistance, contact the eBRAP Help Desk:

• Phone: 301-682-5507
• Email: help@eBRAP.org