Director, US Value & Access

Headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been discovering medical breakthroughs for more than three decades. We’re pioneers in RNA-targeted medicines, revolutionizing drug discovery and transforming lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology, and select areas of high patient needs, we drive innovation in RNA therapies and advance new approaches in gene editing. Our challenging, motivating, and rewarding environment fosters innovation and scientific excellence, and we invest in making our onsite, hybrid, and remote work environments a place where employees thrive.

About the role

The Director, Value & Access leads the development and execution of comprehensive value and market access strategies to ensure optimal patient access and commercial success across the designated therapeutic area. This role integrates cross-functional leadership and collaboration across Commercial, Medical, HEOR, and Regulatory to shape payer strategy, evidence generation, and value communication throughout the product lifecycle. The Director operates as a strategic leader with significant autonomy, influencing enterprise-level decisions.

Responsibilities

• Develop and lead U.S. market access strategies aligned with brand and portfolio objectives across a 3+ year horizon.
• Define value proposition and access roadmap from pre-launch through lifecycle management.
• Shape and implement integrated evidence plans, in partnership with HEOR and Medical Affairs to support access and payer negotiations.
• Serve as the enterprise subject matter expert on access, payer dynamics, and policy trends across the landscape and within specialty and rare disease.
• Oversee development of AMCP dossiers, payer communication tools (including Pre-approval Information Exchange and Payer Value Proposition) and field access tools (including product coverage, prior authorization criteria, and patient support options).
• Guide economic modeling and budget impact analyses to support payer discussions.
• Collaborate and partner closely with Commercial to align access strategy with brand strategy.
• Engage with Government Affairs on policy implications and advocacy priorities.
• Represent the organization in external advisory boards and industry forums.
• Monitor payer landscape, competitive dynamics, and regulatory changes to inform strategy.
• Lead, coach, and develop high-performing Market Access professionals.
• Select and retain agency partners, holding full budget authority for access strategies.
• Drive cross-functional alignment in matrixed environments.

Requirements

• Bachelor’s degree required; advanced degree preferred.
• 15+ years of experience with a Bachelor’s degree (or 10+ with advanced degree) in U.S. Market Access, Value & Access, Payer Marketing, or related roles.
• Proven experience leading access strategy for product launches with a strong understanding of U.S. payer systems and reimbursement pathways.
• Experience with specialty pharmaceuticals and/or rare disease preferred.
• Demonstrated collaboration and leadership experience in matrixed organizations.

Benefits

Ionis offers an excellent benefits package. Learn more about our benefits.

Pay

The pay scale for this position is $220,000 to $260,000.